Kentsin
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Cat.No：CLP1755 Solarbio
CAS：56767-30-7
Purity：≥95%
Appearance：Lyophilized powder
Storage：Store at -20℃，2 years.(Avoid freeze/thaw cycles)
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Inhibitors & Antagonists & Agonists
PI3K/Akt/mTOR
Endocrinology & Hormones
Protein Tyrosine Kinase/PTK
Angiogenesis
HIF
Immunology & Inflammation
Stem Cells
Apoptosis
Metabolic Enzyme & Protease
Autophagy
ER Stress
Cell Cycle
Cytoskeleton
DNA Damage & DNA Repai
Epigenetics
Ubiquitin
JAK/STAT
GPCR & G Protein
Neuronal Signal Pathway
MAPK
NF-κB
Membrane Transporter & Ion Channel
TGF-β/Smad
Hippo
Antibody-drug Conjugate/ADC Related
Others
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Shaker
Vacuum Pump
Other Small Instruments
Instruments
Pipette & Dispenser & Pipette Dispensing Instrument
Oscillating Mixing & Stirring & Dispersing Instrument
Temperature Control & Sampling & Grinding Crushing Instrument
Sterilization & Filtration Instruments
PCR Instrument & Light Glue Instrument
Spectrophotometer
Centrifuge
Shaker
Vacuum Pump
Other Small Instruments
Product Information
| Product Type | Peptides |
| CAS | 56767-30-7 |
| Sequence(1LC) | TPRK |
| Sequence(3LC) | Thr-Pro-Arg-Lys |
| Molecular Formula | C21H40N8O6 |
| Molecular Weight | 500.59 |
| Purity | ≥95% |
| Appearance | Lyophilized powder |
| Salt Form | Trifluoroacetate salt |
| Source | Synthetic |
| Storage | Store at -20℃，2 years.(Avoid freeze/thaw cycles) |
| Category/Label | Other Peptides |
| Background | Kentsin， a contraceptive tetrapeptide， is originally extracted from hamster embryos. Kentsin prevents the maturation of Graafian follicles and consequently inhibits ovulation. Kentsin has opiate properties on gastrointestinal motility. |
| In Vitro | Kentsin (100 μg/mL， 18 h) increases endogenous xenotropic virus expression in K-Balb 19a/h cells transformed with Kirsten sarcoma virus. Kentsin (30 μM) does not inhibit electrically stimulated contractions of the guinea pig ileum (GPI) or mouse vas deferens (MVD). |
| In Vivo | Kentsin (0-100 μg， i.c.v. or intrathecal administration) produces analgesia in both the hotplate and abdominal stretch tests. Kentsin (20 and 100 ng/kg， i.c.v.) inhibits the antral motility index and disrupts the jejunal migrating motor complex in fasted dogs. Kentsin (4.0 μg/kg， i.c.v. 2 hours after the beginning of a meal) restores the “fasted” (the migrating myoelectric complex of intestinal motility)， and can be blocked by previous Naloxone (400 μg/kg， i.c.v.). |
| Reference | [1]. Fox DA， et al. Kentsin: tetrapeptide from hamster embryos produces naloxone-sensitive effects without binding to opioid receptors. Peptides. 1987 Jul-Aug;8(4):613-8. [2]. Suk WA， et al. Increased expression of endogenous xenotropic murine retrovirus by treatment with the tetrapeptides， tuftsin and kentsin. J Gen Virol. 1981 Jan;52(Pt 1):189-94. [3]. Bueno L， et al. Central opioid-like influence of a tetrapeptide from hamster embryo (kentsin) on gastrointestinal motility in dogs. Eur J Pharmacol. 1985 Aug 7;114(1):67-70. [4]. Buéno L， et al. A tetrapeptide isolated from hamster embryo with central opiate properties on gastrointestinal motility but not on pain perception. Life Sci. 1986 Jul 14;39(2):141-6. [5]. Wieczorek Z， et al. The immunomodulatory activity of tetra- and tripeptides of tuftsin-kentsin group. Peptides. 1994;15(2):215-21. |
| Unit | Bottle |
| Specification | 1mg 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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