Secretin (swine)
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Cat.No：CLP1595 Solarbio
CAS：17034-35-4
Purity：≥95%
Appearance：Lyophilized powder
Storage：Store at -20℃，2 years.(Avoid freeze/thaw cycles)
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Inhibitors & Antagonists & Agonists
PI3K/Akt/mTOR
Endocrinology & Hormones
Protein Tyrosine Kinase/PTK
Angiogenesis
HIF
Immunology & Inflammation
Stem Cells
Apoptosis
Metabolic Enzyme & Protease
Autophagy
ER Stress
Cell Cycle
Cytoskeleton
DNA Damage & DNA Repai
Epigenetics
Ubiquitin
JAK/STAT
GPCR & G Protein
Neuronal Signal Pathway
MAPK
NF-κB
Membrane Transporter & Ion Channel
TGF-β/Smad
Hippo
Antibody-drug Conjugate/ADC Related
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Instruments
Pipette & Dispenser & Pipette Dispensing Instrument
Oscillating Mixing & Stirring & Dispersing Instrument
Temperature Control & Sampling & Grinding Crushing Instrument
Sterilization & Filtration Instruments
PCR Instrument & Light Glue Instrument
Spectrophotometer
Centrifuge
Shaker
Vacuum Pump
Other Small Instruments
Product Information
| Product Type | Peptides |
| CAS | 17034-35-4 |
| Sequence(1LC) | HSDGTFTSELSRLRDSARLQRLLQGLV-NH2 |
| Sequence(3LC) | His-Ser-Asp-Gly-Thr-Phe-Thr-Ser-Glu-Leu-Ser-Arg-Leu-Arg-Asp-Ser-Ala-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Gly-Leu-Val-NH2 |
| Molecular Formula | C130H220N44O41 |
| Molecular Weight | 3055.41 |
| Purity | ≥95% |
| Appearance | Lyophilized powder |
| Solubility | DMSO：66.67 mg/mL; *Ultrasonic solubilization; |
| Salt Form | Trifluoroacetate salt |
| Source | Synthetic |
| Storage | Store at -20℃，2 years.(Avoid freeze/thaw cycles) |
| Category/Label | Hormone and Related Peptides |
| Background | Secretin (swine)， a neuroendocrine hormone， is the first hormone to be identifie and is secreted by S cells that are localized primarily in the mucosa of the duodenum. Secretin also is a 27-amino acid peptide， which acts on secretin receptors. Secretin is expressed by cells in all mature enteroendocrine cell subsets and can be prompted by fatty acids. Secretin stimulates the secretion of pancreatic water and bicarbonate. Secretin exerts various effects in organs， can be used for the research of digestive system， central nervous system and energy metabolism. |
| In Vitro | Secretin (swine) (10?7M， 10?6M; 24 to 72 h and 7 days) stimulates biliary growth by interaction with secretin receptors (SR) and knockout of SR reduces biliary proliferation by downregulating cAMP dependent signaling. Secretin (10?7M， 10?6M; 24 to 72 h and 7 days) increases the proliferation in human HIBEpiC and large murine cholangiocyte lines. |
| In Vivo | Secretin (swine) (2.5 nM/kg， BW/day， osmotic minipumps， for 1 week) stimulates biliary cell proliferation by regulating expression of microRNA 125b and microRNA let7a in mice. |
| Reference | [1]. Katharina Schnabl， et al. Secretin as a Satiation Whisperer With the Potential to Turn into an Obesity-curbing Knight. Endocrinology. 2021 Sep 1;162(9):bqab113. [2]. Shannon Glaser， et al. Secretin stimulates biliary cell proliferation by regulating expression of microRNA 125b and microRNA let7a in mice. Gastroenterology. 2014 Jun;146(7):1795-808.e12. [3]. G Alpini， et al. Morphological， molecular， and functional heterogeneity of cholangiocytes from normal rat liver. Gastroenterology. 1996 May;110(5):1636-43. [4]. Shannon Glaser， et al. Knockout of secretin receptor reduces large cholangiocyte hyperplasia in mice with extrahepatic cholestasis induced by bile duct ligation. Hepatology. 2010 Jul;52(1):204-14. |
| Unit | Bottle |
| Specification | 1mg 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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