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My Cart> Peptides > Hormone and Related Peptides > Adipokinetic hormone II (Locusta migratoria)CAS：98968-94-6
Purity：≥95%
Appearance：Lyophilized powder
Storage：Store at -20℃，2 years.(Avoid freeze/thaw cycles)
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| Product Type | Peptides |
| CAS | 98968-94-6 |
| Sequence(1LC) | pGlu-LNFSAGW-NH2 |
| Sequence(3LC) | Pyr-Leu-Asn-Phe-Ser-Ala-Gly-Trp-NH2 |
| Molecular Formula | C43H57N11O11 |
| Molecular Weight | 903.98 |
| Purity | ≥95% |
| Appearance | Lyophilized powder |
| Salt Form | Trifluoroacetate salt |
| Source | Synthetic |
| Storage | Store at -20℃，2 years.(Avoid freeze/thaw cycles) |
| Category/Label | Hormone and Related Peptides |
| Background | Adipokinetic hormone II (Locusta migratoria) (Lom-AKH-II) is a insect adipokinetic hormone (AKH)， enhances fat body cAMP levels in vitro. Insect adipokinetic hormones (AKHs) controls flight-directed mobilization of carbohydrate and lipid from fat body stores， which depends on AKH receptor(s) coupling to cAMP formation and glycogen phosphorylase activation via the stimulatory guanine nucleotide-binding protein (Gs). |
| In Vitro | Adipokinetic hormone II (Locusta migratoria) (radiolabeled; 1 pmol in 10 μL of 10% methanol; 30 min on ice， and repeated for 2 h at 30 ℃) shows no association with one of the larger protein components， indicating a lack of separate transporting or carrier protein in the hemolymph. Adipokinetic hormones (AKHs) are known to be involved in insect immunity and shows the mechanism of metabolic stimulation， leading a significant increase in carbon dioxide production， and efficacy increase of toxins produced by I. fumosorosea in the cockroach’s body. Adipokinetic hormone II is more effective than hormone I in bringing about an accumulation of cAMP in the fat body. |
| In Vivo | Adipokinetic hormone II (Locusta migratoria) (1 pmol in 10 μL of 10% methanol; injection) plays its own biol. role in the overall syndrome of insect flight， with different half-lives of 40 min and 37 min during rest and flight， respectively. |
| Reference | [1]. Oudejans RC， et al. Locust adipokinetic hormones: carrier-independent transport and differential inactivation at physiological concentrations during rest and flight. Proc Natl Acad Sci U S A. 1996 Aug 6;93(16):8654-9. [2]. Gautam UK， et al. Adipokinetic hormone promotes infection with entomopathogenic fungus Isaria fumosorosea in the cockroach Periplaneta americana. Comp Biochem Physiol C Toxicol Pharmacol. 2020 Mar;229:108677. [3]. Vroemen SF， et al. Stimulation of glycogenolysis by three locust adipokinetic hormones involves Gs and cAMP. Mol Cell Endocrinol. 1995 Feb;107(2):165-71. [4]. Goldsworthy， et al. The relative potencies of two known locust adipokinetic hormones. 1986;32(1):95-101. |
| Unit | Bottle |
| Specification | 1mg 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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