Reltecimod
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Cat.No：CLP1687 Solarbio
CAS：1447799-33-8
Purity：≥95%
Appearance：Lyophilized powder
Storage：Store at -20℃，2 years.(Avoid freeze/thaw cycles)
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Colloidal Gold Reagent
Alkaline Phosphatase(AP)-Conjugated
Colloidal Gold-Conjugated
FITC-Conjugated
Biotin-Conjugated
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Allophycocyanin(APC)-Conjugated
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Inhibitors & Antagonists & Agonists
PI3K/Akt/mTOR
Endocrinology & Hormones
Protein Tyrosine Kinase/PTK
Angiogenesis
HIF
Immunology & Inflammation
Stem Cells
Apoptosis
Metabolic Enzyme & Protease
Autophagy
ER Stress
Cell Cycle
Cytoskeleton
DNA Damage & DNA Repai
Epigenetics
Ubiquitin
JAK/STAT
GPCR & G Protein
Neuronal Signal Pathway
MAPK
NF-κB
Membrane Transporter & Ion Channel
TGF-β/Smad
Hippo
Antibody-drug Conjugate/ADC Related
Others
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Instruments
Pipette & Dispenser & Pipette Dispensing Instrument
Oscillating Mixing & Stirring & Dispersing Instrument
Temperature Control & Sampling & Grinding Crushing Instrument
Sterilization & Filtration Instruments
PCR Instrument & Light Glue Instrument
Spectrophotometer
Centrifuge
Shaker
Vacuum Pump
Other Small Instruments
Product Information
| Product Type | Peptides |
| CAS | 1447799-33-8 |
| Sequence(1LC) | ASPMLVAYDA |
| Sequence(3LC) | Ala-Ser-Pro-Met-Leu-Val-Ala-Tyr-Asp-Ala |
| Molecular Formula | C46H72N10O15S1 |
| Molecular Weight | 1037.19 |
| Purity | ≥95% |
| Appearance | Lyophilized powder |
| Salt Form | Trifluoroacetate salt |
| Source | Synthetic |
| Storage | Store at -20℃，2 years.(Avoid freeze/thaw cycles) |
| Category/Label | Antimicrobial Peptides |
| Background | Reltecimod (AB-103) is a T-cell-specific surface glycoprotein CD28 (TP44) antagonist. Reltecimod has beneficial effects against different bacterial infections， their exotoxins and endotoxins， and ionizing radiation. Reltecimod modulates the inflammatory response by targeting and attenuating the critical CD28/B7-2 co-stimulatory pathway， without inhibiting it. Reltecimod can be used to research necrotizing soft-tissue infections (NSTIs). |
| In Vivo | Reltecimod (1.25-5 mg/kg; i.v.) increases the survival rate of mice infected with different bacteria. |
| Reference | [1]. Shirvan， A.， et al. Reltecimod. T-cell-specific surface glycoprotein CD28 (TP44) antagonist， CD28 homodimer interface mimetic peptide， Treatment of necrotizing soft-tissue infection. Drugs Fut 2018， 43(4): 243[2]. Edgar， R.， Tarrio， M.L.， Maislin， G.?et al.?Treatment with One Dose of Reltecimod is Superior to Two Doses in Mouse Models of Lethal Infection.?Int J Pept Res Ther?26， 1669–1683 (2020). |
| Unit | Bottle |
| Specification | 1mg 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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