CD31
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Cat.No：CLP1636 Solarbio
CAS：161374-99-8
Purity：≥95%
Appearance：Lyophilized powder
Storage：Store at -20℃，2 years.(Avoid freeze/thaw cycles)
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Inhibitors & Antagonists & Agonists
PI3K/Akt/mTOR
Endocrinology & Hormones
Protein Tyrosine Kinase/PTK
Angiogenesis
HIF
Immunology & Inflammation
Stem Cells
Apoptosis
Metabolic Enzyme & Protease
Autophagy
ER Stress
Cell Cycle
Cytoskeleton
DNA Damage & DNA Repai
Epigenetics
Ubiquitin
JAK/STAT
GPCR & G Protein
Neuronal Signal Pathway
MAPK
NF-κB
Membrane Transporter & Ion Channel
TGF-β/Smad
Hippo
Antibody-drug Conjugate/ADC Related
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Instruments
Pipette & Dispenser & Pipette Dispensing Instrument
Oscillating Mixing & Stirring & Dispersing Instrument
Temperature Control & Sampling & Grinding Crushing Instrument
Sterilization & Filtration Instruments
PCR Instrument & Light Glue Instrument
Spectrophotometer
Centrifuge
Shaker
Vacuum Pump
Other Small Instruments
Product Information
| Product Type | Peptides |
| CAS | 161374-99-8 |
| Sequence(1LC) | NHASSVPRSKILTVRVILAPWKK |
| Sequence(3LC) | Asn-His-Ala-Ser-Ser-Val-Pro-Arg-Ser-Lys-Ile-Leu-Thr-Val-Arg-Val-Ile-Leu-Ala-Pro-Trp-Lys-Lys |
| Molecular Formula | C119H202N36O29 |
| Molecular Weight | 2601.1 |
| Purity | ≥95% |
| Appearance | Lyophilized powder |
| Salt Form | Trifluoroacetate salt |
| Source | Synthetic |
| Storage | Store at -20℃，2 years.(Avoid freeze/thaw cycles) |
| Category/Label | Antimicrobial Peptides |
| Background | CD31 (PECAM-1) is platelet endothelial cell adhesion molecule-1， serves as the endothelial cell-specific receptor of clostridium perfringens b-Toxin (CPB). CD31 is also an ER-MP12 antigen， acts as a linker between mechanical stress， metabolism and inflammation. CD31 peptide is able to sustain phosphorylation of the CD31 ITIM686 and of SHP2 and to inhibit TCR-induced T-cell activation-. |
| In Vitro | CD31 is a trans-homophilic co-signaling protein at the crossroad between mechanical stress， metabolism and inflammation. CD31 is a ER-MP12 antigen， exerts function as promoting cell adhesion between endothelial cells， enabling transmigration of leukocytes across vascular endothelium， and producing signaling to up-regulation of other adhesion molecules in neighboring cells. Clostridium perfringens b-toxin (CPB) is a highly active b-pore-forming toxin (b-PFT) and the essential virulence factor for fatal， necro-hemorrhagic enteritis. CD31 serves as the specific membrane receptor for clostridium perfringens b-toxin (CPB) on endothelial cells. CD31 directly interacts with CPB， with the membrane proximal Ig6 domain. CD31 also serves as a therapeutic target in atherosclerosis. CD31 (0， 25， 50， 100 μg/mL) induces proliferative response to TCR engagement of human PBMCs in a dose-dependent manner. |
| Reference | [1]. Caligiuri G. Mechanotransduction， immunoregulation， and metabolic functions of CD31 in cardiovascular pathophysiology. Cardiovasc Res. 2019 Jul 1. 115(9):1425-1434. [2]. Ling V， et al. Structural identification of the hematopoietic progenitor antigen ER-MP12 as the vascular endothelial adhesion molecule PECAM-1 (CD31). Eur J Immunol. 1997 Feb. 27(2):509-14. [3]. Bruggisser J， et al. CD31 (PECAM-1) Serves as the Endothelial Cell-Specific Receptor of Clostridium perfringens β-Toxin. Cell Host Microbe. 2020 Jul 8. 28(1):69-78.e6. [4]. Caligiuri G. CD31 as a Therapeutic Target in Atherosclerosis. Circ Res. 2020 Apr 24. 126(9):1178-1189. [5]. Fornasa G， et al. TCR stimulation drives cleavage and shedding of the ITIM receptor CD31. J Immunol. 2010 May 15. 184(10):5485-92. |
| Unit | Bottle |
| Specification | 1mg 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
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