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My Cart> Peptides > Substrate and Enzyme Inhibitors > VIP(6-28)(human，rat，porcine，bovine)CAS：69698-54-0
Purity：≥95%
Appearance：Lyophilized powder
Storage：Store at -20℃，2 years.(Avoid freeze/thaw cycles)
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| Product Type | Peptides |
| CAS | 69698-54-0 |
| Sequence(1LC) | FTDNYTRLRKQMAVKKYLNSILN-NH2 |
| Sequence(3LC) | Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn-NH2 |
| Molecular Formula | C126H207N37O34S1 |
| Molecular Weight | 2816.28 |
| Purity | ≥95% |
| Appearance | Lyophilized powder |
| Salt Form | Trifluoroacetate salt |
| Source | Synthetic |
| Storage | Store at -20℃，2 years.(Avoid freeze/thaw cycles) |
| Category/Label | Substrate and Enzyme Inhibitors |
| Background | VIP(6-28)(human， rat， porcine， bovine) is an effective antagonist of the actions of exogenous vasoactive intestinal peptide (VIP) on cAMP. |
| In Vitro | VIP(6-28) is an effective VIP antagonist in the superior cervical ganglion (SCG) ， and results obtained using this analog indicate that endogenous VIP can participate in a positive feedback loop in injured sympathetic neurons in which it enhances its own expression. VIP(6-28)， when added to short-term cultures of adult SCG at a concentration of 10， 30， or 100 μM， reduces the increase in cAMP levels produced by stimulation with 10 μM VIP by 52， 64， or 81%， respectively. At any of these concentrations tested， VIP(6-28) by itself does not alter cAMP levels. In contrast to its ability to reduce the VIP-stimulated elevation in cAMP levels by 64%， the addition of 30 μM VIP(6-28) to culture medium does not significantly alter cAMP levels measured after stimulation of adult ganglia with either isoproterenol or forskolin (10 μM each). Similar results on the ability of VIP(6-28) to block VIP-stimulated increases in cAMP levels are obtained in neuron-enriched and in non-neuronal cell-enriched dissociated cultures. |
| Reference | [1]. Mohney RP， et al. Vasoactive intestinal peptide enhances its own expression in sympathetic neurons after injury. J Neurosci. 1998 Jul 15;18(14):5285-93. |
| Unit | Bottle |
| Specification | 1mg 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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