Phyllomedusin
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Cat.No：CLP1422 Solarbio
CAS：26145-48-2
Purity：≥95%
Appearance：Lyophilized powder
Storage：Store at -20℃，2 years.(Avoid freeze/thaw cycles)
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Inhibitors & Antagonists & Agonists
PI3K/Akt/mTOR
Endocrinology & Hormones
Protein Tyrosine Kinase/PTK
Angiogenesis
HIF
Immunology & Inflammation
Stem Cells
Apoptosis
Metabolic Enzyme & Protease
Autophagy
ER Stress
Cell Cycle
Cytoskeleton
DNA Damage & DNA Repai
Epigenetics
Ubiquitin
JAK/STAT
GPCR & G Protein
Neuronal Signal Pathway
MAPK
NF-κB
Membrane Transporter & Ion Channel
TGF-β/Smad
Hippo
Antibody-drug Conjugate/ADC Related
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Instruments
Pipette & Dispenser & Pipette Dispensing Instrument
Oscillating Mixing & Stirring & Dispersing Instrument
Temperature Control & Sampling & Grinding Crushing Instrument
Sterilization & Filtration Instruments
PCR Instrument & Light Glue Instrument
Spectrophotometer
Centrifuge
Shaker
Vacuum Pump
Other Small Instruments
Product Information
| Product Type | Peptides |
| CAS | 26145-48-2 |
| Sequence(1LC) | pGlu-NPNRFIGLM-NH2 |
| Sequence(3LC) | Pyr-Asn-Pro-Asn-Arg-Phe-Ile-Gly-Leu-Met-NH2 |
| Molecular Formula | C52H82N16O13S1 |
| Molecular Weight | 1171.37 |
| Purity | ≥95% |
| Appearance | Lyophilized powder |
| Salt Form | Trifluoroacetate salt |
| Source | Synthetic |
| Storage | Store at -20℃，2 years.(Avoid freeze/thaw cycles) |
| Category/Label | Substrate and Enzyme Inhibitors |
| Background | Phyllomedusin， an tachykinin decapeptide， is a NK1 receptor agonist. Phyllomedusin has vasodilating activity and provokes the contraction of the pylorus. |
| In Vitro | Phyllomedusin increases neuronal excitation with psychoactive and behavioral responses. Phyllomedusin can cause smooth muscle contraction and vasodilatation. |
| In Vivo | Phyllomedusin (30-300 μg/kg， i.p.) delays gastric emptying in conscious rats. Phyllomedusin (0.1 and 5 μg/kg， i.v.) has stimulant activity on the stomach of the anaesthetized rat. |
| Reference | [1]. Ganjiwale AD， et al. Three-dimensional structure of Phyllomedusin， a NK1 receptor agonist bound to dodecylphosphocholine micelles. J Struct Biol. 2009 Aug;167(2):176-84. [2]. Bertaccini G， et al. Effect of substance P and its natural analogues on gastric emptying of the conscious rat. Br J Pharmacol. 1981 Feb;72(2):221-3. [3]. Bertaccini G， et al. Action of some natural peptides on the stomach of the anaesthetized rat. Naunyn Schmiedebergs Arch Pharmacol. 1977 Jun;298(2):163-6. [4]. Sacco MA， et al. Kambo: Natural drug or potential toxic agent? A literature review of acute poisoning cases. Toxicol Rep. 2022 Apr 15;9:905-913. |
| Unit | Bottle |
| Specification | 1mg 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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