Pep2m，myristoylated
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Cat.No：CLP1415 Solarbio
CAS：1423381-07-0
Purity：≥95%
Appearance：Lyophilized powder
Storage：Store at -20℃，2 years.(Avoid freeze/thaw cycles)
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PI3K/Akt/mTOR
Endocrinology & Hormones
Protein Tyrosine Kinase/PTK
Angiogenesis
HIF
Immunology & Inflammation
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Pipette & Dispenser & Pipette Dispensing Instrument
Oscillating Mixing & Stirring & Dispersing Instrument
Temperature Control & Sampling & Grinding Crushing Instrument
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Spectrophotometer
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Product Information
| Product Type | Peptides |
| CAS | 1423381-07-0 |
| Sequence(1LC) | Myr-KRMKVAKNAQ |
| Sequence(3LC) | Myr-Lys-Arg-Met-Lys-Val-Ala-Lys-Asn-Ala-Gln |
| Molecular Formula | C63H118N18O14S1 |
| Molecular Weight | 1383.81 |
| Purity | ≥95% |
| Appearance | Lyophilized powder |
| Salt Form | Trifluoroacetate salt |
| Source | Synthetic |
| Storage | Store at -20℃，2 years.(Avoid freeze/thaw cycles) |
| Category/Label | Substrate and Enzyme Inhibitors |
| Background | Pep2m， myristoylated (Myr-Pep2m) is a cell-permeable peptide. Pep2m， myristoylated can disrupt the protein kinase ζ (PKMζ) downstream targets， N-ethylmaleimide-sensitive factor/glutamate receptor subunit 2 (NSF/GluR2) interactions. PKMζ is an autonomously active isozyme of protein kinase C (PKC). |
| In Vitro | Pep2m， myristoylated (10 μM) blocks PKMζ-mediated AMPA receptor (AMPAR) potentiation. Pep2m， myristoylated does not block the increase of PKMζ in the hippocampal slices during long-term potentiation (LTP) maintenance， indicating that blocking NSF/GluR2 interactions do not prevent the induction of PKMζ synthesis. Pep2m， myristoylated blocks NSF/GluR2-mediated AMPAR trafficking， and reverses persistent potentiation at both the strongly stimulates synapses and the weakly stimulats synapses that underwent synaptic tagging and capture. |
| In Vivo | Pep2m， myristoylated (10 μg/20 μL) results in an increase in paw withdrawal thresholds (PWTs) on nociceptive responses in the formalin test. |
| Reference | [1]. Yudong Yao， et al. PKMζ Maintains Late Long-Term Potentiation by N-Ethylmaleimide-Sensitive Factor/GluR2-Dependent Trafficking of Postsynaptic AMPA Receptors. J Neurosci. 2008 Jul 30; 28(31): 7820-7827. [2]. Nicole C George， et al. Sex differences in the contributions of spinal atypical PKCs and downstream targets to the maintenance of nociceptive sensitization. Mol Pain. 2019; 15: 1744806919840582. |
| Unit | Bottle |
| Specification | 1mg 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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