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NFAT Inhibitor-1

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Cat.No：CLP1387 Solarbio

CAS：249537-73-3

Purity：≥95%

Appearance：Lyophilized powder

Storage：Store at -20℃，2 years.(Avoid freeze/thaw cycles)

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Product Information

Product Type	Peptides
CAS	249537-73-3
Sequence(1LC)	MAGPHPVIVITGPHEE
Sequence(3LC)	Met-Ala-Gly-Pro-His-Pro-Val-Ile-Val-Ile-Thr-Gly-Pro-His-Glu-Glu
Molecular Formula	C75H118N20O22S1
Molecular Weight	1683.93
Purity	≥95%
Appearance	Lyophilized powder
Solubility	H2O：100 mg/mL; *Ultrasonic solubilization;
Salt Form	Trifluoroacetate salt
Source	Synthetic
Storage	Store at -20℃，2 years.(Avoid freeze/thaw cycles)
Category/Label	Substrate and Enzyme Inhibitors
Background	NFAT Inhibitor (VIVIT peptide) is a cell-permeable peptide inhibitor of nuclear factor of activated Tcells (NFAT) that selectively inhibits calcineurin-mediated dephosphorylation of NFAT.
In Vitro	NFAT Inhibitor-1 treatment significantly inhibits nuclear translocation of NFATc1 for 24 hours. Long-term treatment with VIVIT significantly inhibits the cytoplasmic levels of cathepsin K， TRAP， and MMP-9.
Reference	[1]. Aramburu J， et al. Affinity-driven peptide selection of an NFAT inhibitor more selective than cyclosporin A. Science. 1999 Sep 24;285(5436):2129-33. [2]. Ma JD， et al. Activation of the Peroxisome Proliferator-Activated Receptor γ Coactivator 1β/NFATc1 Pathway in Circulating Osteoclast Precursors Associated With Bone Destruction in Rheumatoid Arthritis. Arthritis Rheumatol. 2019 Aug;71(8):1252-1264.
Unit	Bottle
Specification	1mg 5mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.