LPLRF-NH2
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Cat.No：CLP1367 Solarbio
CAS：88280-21-1
Purity：≥95%
Appearance：Lyophilized powder
Storage：Store at -20℃，2 years.(Avoid freeze/thaw cycles)
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Inhibitors & Antagonists & Agonists
PI3K/Akt/mTOR
Endocrinology & Hormones
Protein Tyrosine Kinase/PTK
Angiogenesis
HIF
Immunology & Inflammation
Stem Cells
Apoptosis
Metabolic Enzyme & Protease
Autophagy
ER Stress
Cell Cycle
Cytoskeleton
DNA Damage & DNA Repai
Epigenetics
Ubiquitin
JAK/STAT
GPCR & G Protein
Neuronal Signal Pathway
MAPK
NF-κB
Membrane Transporter & Ion Channel
TGF-β/Smad
Hippo
Antibody-drug Conjugate/ADC Related
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Instruments
Pipette & Dispenser & Pipette Dispensing Instrument
Oscillating Mixing & Stirring & Dispersing Instrument
Temperature Control & Sampling & Grinding Crushing Instrument
Sterilization & Filtration Instruments
PCR Instrument & Light Glue Instrument
Spectrophotometer
Centrifuge
Shaker
Vacuum Pump
Other Small Instruments
Product Information
| Product Type | Peptides |
| CAS | 88280-21-1 |
| Sequence(1LC) | LPLRF-NH2 |
| Sequence(3LC) | Leu-Pro-Leu-Arg-Phe-NH2 |
| Molecular Formula | C32H53N9O5 |
| Molecular Weight | 643.82 |
| Purity | ≥95% |
| Appearance | Lyophilized powder |
| Salt Form | Trifluoroacetate salt |
| Source | Synthetic |
| Storage | Store at -20℃，2 years.(Avoid freeze/thaw cycles) |
| Category/Label | Substrate and Enzyme Inhibitors |
| Background | LPLRF-NH2 is a member of RFamide peptide with anorexigenic effect. LPLRF-NH2 increases arterial blood pressure and modulates the electrical activity of brainstem neurons. |
| In Vitro | YMRF-NH2 (0.1 nM-1 μM) inhibits Forskolin-induced production of cAMP in CHO cells. |
| In Vivo | LPLRF-NH2 (3-15 nmol， ICV) shows anorexigenic effect in chicks. LPLRF-NH2 (25-50 nM/kg， 150 μL， i.v.) increases arterial blood pressure in rats. |
| Reference | [1]. Scheel A， et al. LPLRFamide exerts short-term anorexigenic effects that coincide with magnocellular division of the hypothalamic paraventricular nucleus activation. Gen Comp Endocrinol. 2017 May 15;246:116-119. [2]. Barnard CS， et al. Increases in arterial blood pressure in the rat in response to a new vertebrate neuropeptide， LPLRFamide， and a related molluscan peptide， FMRFamide. Regul Pept. 1984 Apr;8(3):209-15. [3]. Chartrel N， et al. Structure and functions of the novel hypothalamic RFamide neuropeptides R-RFa and 26RFa in vertebrates. Peptides. 2006 May;27(5):1110-20. [4]. Hinuma S， et al. New neuropeptides containing carboxy-terminal RFamide and their receptor in mammals. Nat Cell Biol. 2000 Oct;2(10):703-8. |
| Unit | Bottle |
| Specification | 1mg 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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