Glucagon (22-29)
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Cat.No：CLP1345 Solarbio
CAS：32204-93-6
Purity：≥95%
Appearance：Lyophilized powder
Storage：Store at -20℃，2 years.(Avoid freeze/thaw cycles)
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HIF
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Pipette & Dispenser & Pipette Dispensing Instrument
Oscillating Mixing & Stirring & Dispersing Instrument
Temperature Control & Sampling & Grinding Crushing Instrument
Sterilization & Filtration Instruments
PCR Instrument & Light Glue Instrument
Spectrophotometer
Centrifuge
Shaker
Vacuum Pump
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Product Information
| Product Type | Peptides |
| CAS | 32204-93-6 |
| Sequence(1LC) | FVQWLMNT |
| Sequence(3LC) | Phe-Val-Gln-Trp-Leu-Met-Asn-Thr |
| Molecular Formula | C49H71N11O12S1 |
| Molecular Weight | 1038.22 |
| Purity | ≥95% |
| Appearance | Lyophilized powder |
| Salt Form | Trifluoroacetate salt |
| Source | Synthetic |
| Storage | Store at -20℃，2 years.(Avoid freeze/thaw cycles) |
| Category/Label | Substrate and Enzyme Inhibitors |
| Background | Glucagon (22-29) is partial agonist of Glucagon (19–29). Glucagon specifically inhibits the Ca2+ pump in liver plasma membranes independently of adenylate cyclase activation. |
| In Vitro | Glucagon (22-29) produces only a 5-15% maximal inhibition of (Ca2+-Mg2+) ATPase， with a low potency (Ki=1 μM)， similar to that of native glucagon. Glucagon (22-29) (10 nM) evokes an early small decrease of cell contraction when added alone and an 18% significant positive inotropic effect when added in combination with 30 nM glucagon. Glucagon (22-29) thus appears to act as a partial agonist of miniglucagon. Glucagon (22-29) consists of the COOH-terminal part of miniglucagon but lacks the three Ala1g-Gln20-Asp21 residues. |
| Reference | [1]. Mallat A， et al. A glucagon fragment is responsible for the inhibition of the liver Ca2+ pump by glucagon. Nature. 1987 Feb 12-18;325(6105):620-2. [2]. Pavoine C， et al. Miniglucagon [glucagon-(19-29)] is a component of the positive inotropic effect of glucagon. Am J Physiol. 1991 May;260(5 Pt 1):C993-9. |
| Unit | Bottle |
| Specification | 1mg 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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