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My CartCAS：915091-83-7
Molecular Formula：C100H151N27O29
Molecular Weight：2195.44
Purity：≥95%
Appearance：Lyophilized powder
Storage：Store at -20℃，2 years.(Avoid freeze/thaw cycles)
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| Product Type | Peptides |
| CAS | 915091-83-7 |
| Sequence(1LC) | NENITVPDTKVNFYAWKR |
| Sequence(3LC) | Asn-Glu-Asn-Ile-Thr-Val-Pro-Asp-Thr-Lys-Val-Asn-Phe-Tyr-Ala-Trp-Lys-Arg |
| Molecular Formula | C100H151N27O29 |
| Molecular Weight | 2195.44 |
| Purity | ≥95% |
| Appearance | Lyophilized powder |
| Salt Form | Trifluoroacetate salt |
| Source | Synthetic |
| Storage | Store at -20℃，2 years.(Avoid freeze/thaw cycles) |
| Category/Label | Substrate and Enzyme Inhibitors |
| Background | Epobis， a dendrimeric peptide， is a recombinant form of erythropoietin. Epobis is a potent erythropoietin receptor agonist. Epobis promotes neuritogenesis in primary motoneurons. Epobis decrease TNF release and crosses the blood-brain barrier. Epobis has anti-inflammatory and memory enhancing properties. |
| In Vitro | Epobis (0-8.82 μM) stimulates neurite outgrowth from motor neurons in a dose-dependent manner with maximal stimulation at 0.33?μM. Epobis (0-8.82 μM; 24 h) reduces release of TNF and improves the survival of the L929 cells. |
| In Vivo | Epobis (10 mg/kg; i.h.; Wistar rats) can cross the blood-brain barrier (BBB). Epobis (10 mg/kg; i.h.) has an anti-inflammatory effect in mice of multiple sclerosis model. Epobis (10 mg/kg; i.h.; old (>18 month) rats and in rats experiencing early stage AD) improves social memory. |
| Reference | [1]. Dmytriyeva O， et， al. Epobis is a Nonerythropoietic and Neuroprotective Agonist of the Erythropoietin Receptor with Anti-Inflammatory and Memory Enhancing Effects. Mediators Inflamm. 2016;2016:1346390. |
| Unit | Bottle |
| Specification | 1mg 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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