Bax inhibitor peptide V5
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Cat.No：CLP1296 Solarbio
CAS：579492-81-2
Purity：≥95%
Appearance：Lyophilized powder
Storage：Store at -20℃，2 years.(Avoid freeze/thaw cycles)
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Colloidal Gold Reagent
Alkaline Phosphatase(AP)-Conjugated
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Allophycocyanin(APC)-Conjugated
CY Fluorescent-Conjugated
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Inhibitors & Antagonists & Agonists
PI3K/Akt/mTOR
Endocrinology & Hormones
Protein Tyrosine Kinase/PTK
Angiogenesis
HIF
Immunology & Inflammation
Stem Cells
Apoptosis
Metabolic Enzyme & Protease
Autophagy
ER Stress
Cell Cycle
Cytoskeleton
DNA Damage & DNA Repai
Epigenetics
Ubiquitin
JAK/STAT
GPCR & G Protein
Neuronal Signal Pathway
MAPK
NF-κB
Membrane Transporter & Ion Channel
TGF-β/Smad
Hippo
Antibody-drug Conjugate/ADC Related
Others
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Instruments
Pipette & Dispenser & Pipette Dispensing Instrument
Oscillating Mixing & Stirring & Dispersing Instrument
Temperature Control & Sampling & Grinding Crushing Instrument
Sterilization & Filtration Instruments
PCR Instrument & Light Glue Instrument
Spectrophotometer
Centrifuge
Shaker
Vacuum Pump
Other Small Instruments
Product Information
| Product Type | Peptides |
| CAS | 579492-81-2 |
| Sequence(1LC) | VPMLK |
| Sequence(3LC) | Val-Pro-Met-Leu-Lys |
| Molecular Formula | C27H50N6O6S1 |
| Molecular Weight | 586.79 |
| Purity | ≥95% |
| Appearance | Lyophilized powder |
| Solubility | DMSO：≥ 100 mg/mL; H2O：100 mg/mL; *Ultrasonic solubilization; |
| Salt Form | Trifluoroacetate salt |
| Source | Synthetic |
| Storage | Store at -20℃，2 years.(Avoid freeze/thaw cycles) |
| Category/Label | Substrate and Enzyme Inhibitors |
| Background | Bax inhibitor peptide V5 (BIP-V5) is a Bax-mediated apoptosis inhibitor， used for cancer treatment. |
| In Vitro | Bax inhibitor peptide V5 (BIP-V5; 0-50 μM) reduces cell death in STF-cMyc cells but not in SW620 or NCI-H23 cells. BIPV5 does not result in any significant effect on cell cycle arrest at the G2/M phase. V5 treatment upregulates expression of anti-apoptotic proteins Bcl-2 and XIAP by more than 3- and 11-fold and downregulates expression of apoptosis-inducing proteins Bax， Bad， and nuclear factor-κB-p65 by 10， 30， and nearly 50%， respectively. |
| In Vivo | Bax inhibitor peptide V5 (BIP-V5; 100 μM) significantly improves islet function following isolation and improves islet graft function following transplantation in mice model. |
| Reference | [1]. Jo MJ， et al. Regulation of cancer cell death by a novel compound， C604， in a c-Myc-overexpressing cellular environment. Eur J Pharmacol. 2015 Dec 15;769:257-65. [2]. Rivas-Carrillo JD， et al. Cell-permeable pentapeptide V5 inhibits apoptosis and enhances insulin secretion， allowing experimental single-donor islet transplantation in mice. Diabetes. 2007 May;56(5):1259-67. Epub 2007 Feb 7. |
| Unit | Bottle |
| Specification | 1mg 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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