{{cart_num}}
My Cart> Peptides > Substrate and Enzyme Inhibitors > [D-Pro4，D-Trp7，9] Substance P (4-11)CAS：81039-85-2
Purity：≥95%
Appearance：Lyophilized powder
Storage：Store at -20℃，2 years.(Avoid freeze/thaw cycles)
Qty：
Size：
| Product Type | Peptides |
| CAS | 81039-85-2 |
| Sequence(1LC) | PQQWFWLM-NH2 |
| Sequence(3LC) | Pro-Gln-Gln-Trp-Phe-Trp-Leu-Met-NH2 |
| Molecular Formula | C57H75N13O10S1 |
| Molecular Weight | 1134.35 |
| Purity | ≥95% |
| Appearance | Lyophilized powder |
| Salt Form | Trifluoroacetate salt |
| Source | Synthetic |
| Storage | Store at -20℃，2 years.(Avoid freeze/thaw cycles) |
| Category/Label | Substrate and Enzyme Inhibitors |
| Background | [D-Pro4，D-Trp7，9] Substance P (4-11) is a potent antagonist of Substance P (HY-P0201). [D-Pro4，D-Trp7，9] Substance P (4-11) decreases plasma aldosterone (ALDO) concentration. |
| In Vivo | [D-Pro4，D-Trp7，9] Substance P (4-11) inhibits the hypotensive effect of Substance P in anesthetized rats， the vasodilator effect in the rabbit perfused heart， relaxation induced by Substance P in dog carotid arteries contracted with noradrenaline， and stimulatory actions of Substance P in the guinea pig ileum and the guinea pig trachea. [D-Pro4，D-Trp7，9] Substance P (4-11) (0.3 nM/K/min; i.p. for 7 days) significantly decreases plasma aldosterone (ALDO) concentration and causes atrophy of adrenal zona glomerulosa (ZG) and its parenchymal cells. |
| Reference | [1]. Mizrahi J， et al. Substance P antagonists active in vitro and in vivo. Eur J Pharmacol. 1982 Aug 13;82(1-2):101-5. [2]. Mazzocchi G， et al. Evidence that endogenous substance-P (SP) is involved in the maintenance of the growth and steroidogenic capacity of rat adrenal zona glomerulosa. Neuropeptides. 1995 Jul;29(1):53-8. |
| Unit | Bottle |
| Specification | 1mg 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
Sorry, there is no experimental images.
Sorry, there is no more information.
Sorry, there is no more information.
Manual Download
