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My CartStorage：Store at -20℃，2 years.Avoid freeze/thaw cycles.
Appearance：Lyophilized powder
Application： Blocking Peptide of K109638P Antibody
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| Name | RELB Antibody Blocking Peptide |
| Appearance | Lyophilized powder |
| Storage | Store at -20℃，2 years.Avoid freeze/thaw cycles. |
| Swiss Prot | Q01201 |
| Gene ID | 5971 |
| Interval Range | 115-165/579aa |
| Background | NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation， immunity， differentiation， cell growth， tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65， RELB， NFKB1/p105， NFKB1/p50， REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors， respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway， I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators， subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric RelB-p50 and RelB-p52 complexes are transcriptional activators. RELB neither associates with DNA nor with RELA/p65 or REL. Stimulates promoter activity in the presence of NFKB2/p49. As a member of the NUPR1/RELB/IER3 survival pathway， may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress， such as starvation or gemcitabine treatment. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer in a CRY1/CRY2 independent manner. Increased repression of the heterodimer is seen in the presence of NFKB2/p52. Is required for both T and B lymphocyte maturation and function (PubMed:26385063). |
| Application | Blocking Peptide of K109638P Antibody |
| Source | Synthetic |
| Purification Method | HPLC |
| Biological Activity | Not tested |
| Unit | Piece |
| Specification | 500ug |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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