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My CartStorage：Store at -20℃，2 years.Avoid freeze/thaw cycles.
Appearance：Lyophilized powder
Gene ID：10498
Application：Blocking Peptide of K109247P Antibody
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| Name | CARM1 Antibody Blocking Peptide |
| Appearance | Lyophilized powder |
| Storage | Store at -20℃，2 years.Avoid freeze/thaw cycles. |
| Swiss Prot | Q86X55 |
| Gene ID | 10498 |
| Interval Range | 470-520/608aa |
| Background | Methylates (mono- and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in several proteins involved in DNA packaging， transcription regulation， pre-mRNA splicing， and mRNA stability. Recruited to promoters upon gene activation together with histone acetyltransferases from EP300/P300 and p160 families， methylates histone H3 at ’Arg-17’ (H3R17me)， forming mainly asymmetric dimethylarginine (H3R17me2a)， leading to activate transcription via chromatin remodeling. During nuclear hormone receptor activation and TCF7L2/TCF4 activation， acts synergically with EP300/P300 and either one of the p160 histone acetyltransferases NCOA1/SRC1， NCOA2/GRIP1 and NCOA3/ACTR or CTNNB1/beta-catenin to activate transcription. During myogenic transcriptional activation， acts together with NCOA3/ACTR as a coactivator for MEF2C. During monocyte inflammatory stimulation， acts together with EP300/P300 as a coactivator for NF-kappa-B. Acts as coactivator for PPARG， promotes adipocyte differentiation and the accumulation of brown fat tissue. Plays a role in the regulation of pre-mRNA alternative splicing by methylation of splicing factors. Also seems to be involved in p53/TP53 transcriptional activation. Methylates EP300/P300， both at ’Arg-2142’， which may loosen its interaction with NCOA2/GRIP1， and at ’Arg-580’ and ’Arg-604’ in the KIX domain， which impairs its interaction with CREB and inhibits CREB-dependent transcriptional activation. Also methylates arginine residues in RNA-binding proteins PABPC1， ELAVL1 and ELAV4， which may affect their mRNA-stabilizing properties and the half-life of their target mRNAs. |
| Application | Blocking Peptide of K109247P Antibody |
| Source | Synthetic |
| Purification Method | HPLC |
| Biological Activity | Not tested |
| Unit | Piece |
| Specification | 500ug |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
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3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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