Anti-TRIM35 Polyclonal Antibody
Cat.No:K114915P Solarbio
Reactivity:Mouse,Rat,Human
Application: IHC
Storage:Store at -20℃. Avoid freeze / thaw cycles.
Host:Rabbit
Qty:
Size:
{{cart_num}}
My CartReactivity:Mouse,Rat,Human
Application: IHC
Storage:Store at -20℃. Avoid freeze / thaw cycles.
Host:Rabbit
Qty:
Size:
Name | Anti-TRIM35 Polyclonal Antibody |
Host | Rabbit |
Clone Type | Polyclonal Antibody |
Subtype | IgG |
Dilution Ratio | IHC 1:25-100. |
Target | TRIM35 |
Background | E3 ubiquitin-protein ligase that participates in multiple biological processes including cell death, glucose metabolism, and in particular, the innate immune response. Mediates 'Lys-63'-linked polyubiquitination of TRAF3 thereby promoting type I interferon production via RIG-I signaling pathway (PubMed:32562145).Can also catalyze 'Lys-48'-linked polyubiquitination and proteasomal degradation of viral proteins such as influenza virus PB2 (PubMed:32562145).Acts as a negative feedback regulator of TLR7- and TLR9-triggered signaling. Mechanistically, promotes the 'Lys-48'-linked ubiquitination of IRF7 and induces its degradation via a proteasome-dependent pathway (PubMed:25907537).Reduces FGFR1-dependent tyrosine phosphorylation of PKM, inhibiting PKM-dependent lactate production, glucose metabolism, and cell growth (PubMed:25263439). |
Swiss Prot | Q9UPQ4 |
Gene ID | 23087 |
Subcellular Location | Nucleus Cytoplasm |
Immunogen | Recombinant protein of human TRIM35 |
Public Immunogen Range | 1-207aa |
Calculated MW | 56/57kDa |
Purification Method | Affinity purification |
Storage Buffer | PBS with 50% Glycerol, 0.03% Proclin300, 0.5% BSA, pH 7.3. |
Storage | Store at -20℃. Avoid freeze / thaw cycles. |
Piece | Piece |
Specification | 50ul 100ul |
Reactivity | Human Mouse Rat |
Application | IHC |
Remark:These protocols are for reference only. Solarbio does not independently validate these methods.
Kindly reminder:Quick spin before use. If you have any questions, please contact us.
Note:
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
Sorry, there is no experimental images.
Sorry, there is no more information.
Sorry, there is no more information.