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Application： ELISA
Reactivity：Human
Sensitivity：7.8125pg/mL
Storage：2-8℃，6 months
Qty：
Size：
| Name | Human TIM-3 ELISA Kit |
| Storage | 2-8℃，6 months |
| Detection Target | TIM-3 |
| Sample Type | Serum，Plasma，Cell Culture Supernatant |
| Reactivity | Human |
| Application | ELISA |
| Quantitative/Qualitative | Quantitative |
| Detection Range | 15.625-1000pg/mL |
| Sensitivity | 7.8125pg/mL |
| Precision | Both intra-plate and inter-plate variation coefficients were less than 10% |
| Recovery | 80%-120% |
| Swiss Prot | Q8TDQ0 |
| Gene ID | 84868 |
| Background | TIM-3 (T cell immunoglobulin and mucin domain-3)，also known as HAVCR2 is an immunosuppressive protein that enhances tolerance and inhibits anti-tumor immunity. It is upregulated on several populations of activated myeloid cells (macrophage，monocyte，dendritic cell，microglia，mast cell) and T cells (Th1，CD8+，NK，Treg). TIM-3 ligation by Galectin-9 attenuates CD8+ and Th1 cell responses and promotes the activity of Treg and myeloid derived suppressor cells. Dendritic cell-expressed TIM-3 dampens inflammation by enabling the phagocytosis of apoptotic cells and the cross-presentation of apoptotic cell antigens. TIM-3 also binds the alarmin HMGB1，thereby preventing the activation of TLRs in response to released tumor cell DNA. |
| Unit | Kit |
| Specification | 48T 96T |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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