Macrophages Depletion Reagent Set
Cat.No：L9150 Solarbio
Storage：Store at 2-8℃，4 months
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Angiogenesis
HIF
Immunology & Inflammation
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ER Stress
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DNA Damage & DNA Repai
Epigenetics
Ubiquitin
JAK/STAT
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Oscillating Mixing & Stirring & Dispersing Instrument
Temperature Control & Sampling & Grinding Crushing Instrument
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Product Information
| Name | Macrophages Depletion Reagent Set |
| Storage | Store at 2-8℃，4 months |
| Concentration | Clodronate disodium: 4mg/mL |
| Solvent | 10mM Na2HPO4, 10mM NaH2PO4, 140mM NaCl |
| Unit | Set |
| Specification | 2*5ml 2*10ml |
Component:
Clodronate liposomes 5ml, PBS liposomes 5ml
Particle size:
200-400nm
Product Introduction:
Using the endocytosis mechanism of macrophages, clodronate, which is permeable to the membrane, is brought into the cell, and clodronate is released. When it reaches a certain concentration, it can induce apoptosis of macrophages, so as to achieve the purpose of removing macrophages.
How it works:
Amphiphilic phospholipids in water can form concentric circles of phospholipid bilayer spheres separated by water phase. The chlorophosphonate dissolved in aqueous solution is encapsulated in the water phase between the phospholipid bilayer during the process of liposome formation. Free clodronate cannot pass freely through the phospholipid bilayer of liposomes. As liposomes are engulfed by macrophages, clodronate dissolved in the water phase of liposomes can be gradually released and accumulated in cells under the action of macrophage lysosomal phosphonase. When it reaches a certain concentration, macrophages will be irreversibly damaged, thus entering the process of apoptosis. Clodronate released from dying macrophages has an extremely short half-life outside the cell (about 15 min) and can be eliminated outside the body via the urinary system.
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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