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My CartCAS：74588-78-6
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Light yellow to yellow Solid
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| CAS | 74588-78-6 |
| Name | D-64131 |
| Molecular Formula | C16H13NO2 |
| Molecular Weight | 251.28 |
| Solubility | Soluble in DMSO ≥3mg/mL(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD04039791 |
| SMILES | COC1=CC2=C(C=C1)NC(=C2)C(=O)C3=CC=CC=C3 |
| InChIKey | ICMIJSRDISNKOC-UHFFFAOYSA-N |
| InChI | InChI=1S/C16H13NO2/c1-19-13-7-8-14-12(9-13)10-15(17-14)16(18)11-5-3-2-4-6-11/h2-10，17H，1H3 |
| PubChem CID | 3921152 |
| Target Point | Microtubule/Tubulin |
| Passage | Cytoskeleton |
| Background | D-64131 is a tubulin polymerization inhibitor that competitively binds alpha-β-tubulin with colchicine. |
| Biological Activity | D-64131 is an orally active tubulin inhibitor， with an IC50 of 0.53 μM for tubulin polymerization. D-64131 has antimitotic activity. D-64131 can be used for cancer research[1][2]. |
| IC50 | IC50: 0.53 μM (tubulin polymerization)[2] |
| In Vitro | D-64131 is antimitotic by binding to β-tubulin， thereby destabilizing microtubules and arresting mitotic cells in the M-phase[1].D-64131 inhibits the proliferation of tumor cells from 12 of 14 different organs and tissues with mean IC50s of 62 nM[1].D-64131 is cytotoxic toward MDR/MRP tumor cell lines[1].D-64131 suppresses U373 proliferation and cell cycle with IC50s of 74 nM and 62.7nM， respectively[2]. |
| In Vivo | D-64131 (200-400 mg/kg; p.o.; daily; days 1-5， 8-9， and 15-18) significantly inhibits tumor growth in the human amelanoic melanoma MEXF 989 tumor xenograft mice model[1].D-64131 has oral bioavailability and is well tolerated at efficacious doses[1]. |
| Data Literature Source | [1]. Thomas Beckers，et al. 2-Aroylindoles，a novel class of potent，orally active small molecule tubulin inhibitors. Cancer Research (2002)，62(11)，3113-3119. [2]. S Mahboobi，et al. Synthetic 2-aroylindole derivatives as a new class of potent tubulin-inhibitory，antimitotic agents. J Med Chem. 2001 Dec 20;44(26):4535-53. |
| Unit | Bottle |
| Specification | 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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