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My Cart> Biochemical Reagents > Nucleic Acids & Nucleotides & Derivatives > 5-Fluorouracil
CAS：51-21-8
Appearance：White Powder
Storage：Store at 2-8℃，2 years
Purity：≥99.0%
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| Name | 5-Fluorouracil |
| CAS | 51-21-8 |
| Molecular Formula | C4H3FN2O2 |
| Molecular Weight | 130.08 |
| Storage | Store at 2-8℃，2 years |
| Appearance | White Powder |
| Purity | ≥99.0% |
| Solubility | 50mg/mL 1M NaOH |
| Unit | Bottle |
| Specification | 5g |
Product introduction
Purpose and description: Scientific research reagent, widely used in molecular biology, pharmacology and other scientific research. It is converted to 5-fluoro-2-deoxyuracil nucleotide in vivo, which inhibits thymidine nucleotide synthetase and blocks the conversion of deoxyuracil nucleotide to deoxythymidine nucleotide, thereby inhibiting DNA biosynthesis. In addition, the inhibition of RNA synthesis was achieved by preventing the incorporation of uracil and orotic acid into RNA. This drug is a cell cycle specific drug, mainly inhibit S phase cells (for reference only).
Physical properties
melting point 282-286℃(lit.); Slightly soluble in water, slightly soluble in ethanol, almost insoluble in trichloromethane; Dissolved in dilute hydrochloric acid or sodium hydroxide solution;
density 1.54 g/cm3 (predicted)
dry weight loss: ≤0.5%
content: 98.0-102.0%
IC50: COLO 320DM: IC50 = 1.1 μM (human); HeLa: IC50 = 1 μM (human); L1210: IC50 = 0.63 μM (mouse); HaCaT: IC50 = 0.4 μM (human); PC-3: IC50 = 16 nM (human)
median lethal dose (LD50) oral -rat -230 mg/kg
Note：Product information may be optimized and upgraded. Please refer to the actual label information for accuracy.
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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Amino acid permease RcAAP1 increases the uptake and phloem translocation of an L-valine-phenazine-1-carboxylic acid conjugate
Click to check >>Author：Xiao Yongxin, Hu Ciyin, Hsiang Tom, Li Junkai
IF：5.6000
Publish_to：Frontiers in Plant Science
PMID：37332709
2022-07-04 14:12:21