Lisinopril
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Cat.No：IL2420 Solarbio
CAS：76547-98-3
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Solid
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> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Metabolic Enzyme & Protease > Lisinopril
Product Information
| CAS | 76547-98-3 |
| Name | Lisinopril |
| Molecular Formula | C21H31N3O5 |
| Molecular Weight | 405.49 |
| Solubility | Soluble in Water ≥10mg/mL |
| Purity | ≥98% |
| Appearance | Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00214086 |
| SMILES | C1CC(N(C1)C(=O)C(CCCCN)NC(CCC2=CC=CC=C2)C(=O)O)C(=O)O |
| InChIKey | RLAWWYSOJDYHDC-BZSNNMDCSA-N |
| InChI | InChI=1S/C21H31N3O5/c22-13-5-4-9-16(19(25)24-14-6-10-18(24)21(28)29)23-17(20(26)27)12-11-15-7-2-1-3-8-15/h1-3，7-8，16-18，23H，4-6，9-14，22H2，(H，26，27)(H，28，29)/t16-，17-，18-/m0/s1 |
| PubChem CID | 5362119 |
| Target Point | Angiotensin-converting Enzyme (ACE) |
| Passage | Metabolic Enzyme&Protease |
| Background | It is an Angiotensin-converting enzyme ACE inhibitor, which can be used in research related to hypertension, congestive heart failure and heart disease. |
| Biological Activity | Lisinopril (MK-521) is angiotensin-converting enzyme inhibitor， used in treatment of hypertension， congestive heart failure， and heart attacks. |
| IC50 | ACE. |
| In Vitro | Lisinopril is a potent， competitive inhibitor of angiotensin-converting enzyme (ACE)， the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Lisinopril may be used to treat hypertension and symptomatic congestive heart failure， to improve survival in certain individuals following myocardial infarction， and to prevent progression of renal disease in hypertensive patients with diabetes mellitus and microalbuminuria or overt nephropathy[1][2]. |
| Data Literature Source | [1]. Andujar-Sanchez，M.，V. Jara-Perez，and A. Camara-Artigas，Thermodynamic determination of the binding constants of angiotensin-converting enzyme inhibitors by a displacement method. FEBS Lett，2007. 581(18): p. 3449-54. [2]. Song，J.C. and C.M. White，Clinical pharmacokinetics and selective pharmacodynamics of new angiotensin converting enzyme inhibitors: an update. Clin Pharmacokinet，2002. 41(3): p. 207-24. |
| Unit | Bottle |
| Specification | 500mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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