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My CartCAS：57-71-6
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Solid
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| CAS | 57-71-6 |
| Name | 2,3-Butanedione monoxime |
| Molecular Formula | C4H7NO2 |
| Molecular Weight | 101.1 |
| Solubility | Soluble in DMSO(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00002116 |
| SMILES | C/C(=N\O)/C(=O)C |
| InChIKey | FSEUPUDHEBLWJY-HWKANZROSA-N |
| InChI | InChI=1S/C4H7NO2/c1-3(5-7)4(2)6/h7H，1-2H3/b5-3+ |
| PubChem CID | 6409633 |
| Target Point | Myosin |
| Passage | Cytoskeleton |
| Background | 2,3-Butanedione monoxime is a myosin ATPase inhibitor. 2,3-Butanedione monoxime is also a non-competitive inhibitor of skeletal muscle myosin II (myosin II). 2,3-Butanedione monoxime induces Ca2+release from sarcoplasmic reticulum. |
| Biological Activity | Biacetyl monoxime (Diacetyl monoxime)， a myosin ATPase inhibitor， is a skeletal and cardiac muscle contraction inhibitor. Biacetyl monoxime is also a well-characterized non-competitive inhibitor of chemical and motile activity of skeletal muscle myosin-II. Biacetyl monoxime induces sarcoplasmic reticulum Ca2+ release[1-3]. |
| In Vitro | Biacetyl monoxime(50 mM，2 and 4 h)disrupts the localization of the Golgi apparatus，but not that of the endoplasmic reticulum[1].Biacetyl monoxime(0-30 mM)induces SR Ca2+ release(no efflux inhibitors)in a concentration-dependent manner，with a maximal reduction of 72% of SR Ca2+ at pCa 6.0.Biacetyl monoxime acts as a chemical phosphatase，which has led to speculation that dephosphorylation of key Ca2+ channel proteins may be involved in its inhibition of contraction[2].Biacetyl monoxime does not inhibit the ATPase activity of two different myosin-I isoforms，myosin-V，or myosin-VI[3]. |
| Data Literature Source | [1]. Kohsuke Hashimoto，et al. The myosin ATPase inhibitor，2，3-butanedione 2-monoxime，prevents protein secretion by the basidiomycete Coprinopsis cinerea. Biotechnol Lett. 2011 Apr;33(4):769-75. [2]. R M Phillips，et al. 2，3-Butanedione 2-monoxime (BDM) induces calcium release from canine cardiac sarcoplasmic reticulum. Biochem Biophys Res Commun. 1996 Dec 4;229(1):154-7. [3]. Ostap EM. 2，3-Butanedione monoxime (BDM) as a myosin inhibitor. J Muscle Res Cell Motil. 2002;23(4):305-8 |
| Unit | Bottle |
| Specification | 100mg 500mg 1g |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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