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(S)-ML753286

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Cat.No：IM4520 Solarbio

CAS：1699720-85-8

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：Solid

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Product Information

CAS	1699720-85-8
Name	(S)-ML753286
Molecular Formula	C₂₀H₂₅N₃O₃
Molecular Weight	355.43
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
SMILES	CC1C(=O)N2C(CC3=C(C2CC(C)C)NC4=C3C=CC(=C4)OC)C(=O)N1
InChIKey	XDVXQQDQFWVCAU-GOPGUHFVSA-N
InChI	InChI=1S/C20H25N3O3/c1-10(2)7-16-18-14(13-6-5-12(26-4)8-15(13)22-18)9-17-19(24)21-11(3)20(25)23(16)17/h5-6，8，10-11，16-17，22H，7，9H2，1-4H3，(H，21，24)/t11-，16-，17-/m0/s1
PubChem CID	91669184
Target Point	BCRP
Passage	Membrane Transporter&Ion Channel
Background	(S)-ML753286 is a BCRP inhibitor.
Biological Activity	(S)-ML753286 is a breast cancer resistance protein (BCRP) inhibitor with an IC50 of 0.6 μM on BCRP efflux transporter.[1]
IC50	IC50: 0.6μM(BCRP efflux transporter)[1]
In Vivo	(S)-ML753286(Compound A)shows the potency and a potent pharmacokinetic(PK)profile in rats(lower clearance [1.54 L/h/kg] and higher bioavailability [123%]). XL388 has moderate terminal elimination half-life with t1/2s of 0.9 h and 2.0 h for 2 mg/kg(iv)and 20 mg/kg(po)in rats，respectively[1].
Data Literature Source	[1]. Li Y，et al. Synthesis of a new inhibitor of breast cancer resistance protein with significantly improved pharmacokinetic profiles. Bioorg Med Chem Lett. 2016 Jan 15;26(2):551-555.
Unit	Bottle
Specification	5mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.

3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.

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