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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Membrane Transporter & Ion Channel > R(+)-MethylindazoneCAS：54197-31-8
Molecular Formula：C17H18Cl2O4
Molecular Weight：357.23
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to yellow Solid
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| CAS | 54197-31-8 |
| Name | R(+)-Methylindazone |
| Molecular Formula | C17H18Cl2O4 |
| Molecular Weight | 357.23 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD28133534 |
| SMILES | CC1(CC2=CC(=C(C(=C2C1=O)Cl)Cl)OCC(=O)O)C3CCCC3 |
| InChIKey | RNOJGTHBMJBOSP-KRWDZBQOSA-N |
| InChI | InChI=1S/C17H18Cl2O4/c1-17(10-4-2-3-5-10)7-9-6-11(23-8-12(20)21)14(18)15(19)13(9)16(17)22/h6，10H，2-5，7-8H2，1H3，(H，20，21)/t17-/m0/s1 |
| PubChem CID | 656717 |
| Target Point | Chloride Channel |
| Passage | Membrane Transporter&Ion Channel |
| Background | It is a powerful chloride channels blocker. |
| Biological Activity | R(+)-Methylindazone 是氯离子通道阻滞剂。R(+)-Methylindazone 能显著抑制 Nef-sdAb19 的相互作用，并能与 Nef 结合。[1-2] |
| In Vitro | R(+)-Methylindazone is a high-affinity ligand for the chloride channel.[1] R(+)-Methylindazone significantly inhibit the Nef-sdAb19 interaction and to bind to Nef. [2] |
| Data Literature Source | [1]. Landry DW，et al. Purification and reconstitution of chloride channels from kidney and trachea. Science. 1989 Jun 23;244(4911):1469-72. [2]. Fan X，et al. A homogeneous time-resolved fluorescence-based high-throughput screening for discovery of inhibitors of Nef-sdAb19 interaction. Int J Oncol. 2015 Oct;47(4):1485-93. |
| Unit | Bottle |
| Specification | 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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