BiP inducer X
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Cat.No：IB3101 Solarbio
CAS：101714-41-4
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥95%
Appearance：Solid
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> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > ER Stress > BiP inducer X
Product Information
| CAS | 101714-41-4 |
| Name | BiP inducer X |
| Molecular Formula | C9H7NO3S |
| Molecular Weight | 209.22 |
| Solubility | Soluble in DMSO |
| Purity | ≥95% |
| Appearance | Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD22415334 |
| SMILES | C1=CC(=C(C=C1C(=O)CSC#N)O)O |
| InChIKey | SVFLBLCWKKQKDW-UHFFFAOYSA-N |
| InChI | InChI=1S/C9H7NO3S/c10-5-14-4-9(13)6-1-2-7(11)8(12)3-6/h1-3，11-12H，4H2 |
| PubChem CID | 16656807 |
| Target Point | ER Stress inhibitor;BiP/GRP78 |
| Passage | ER Stress |
| Background | BiP inducer X is a selective inducer of immunoglobulin Heavy Chain binding protein (BiP)/GRP79 and is an effective ER stress inhibitor. |
| Biological Activity | BiP inducer X， a selective inducer of immunoglobulin heavy chain binding protein (BiP)/GRP78， is an effective ER (endoplasmic reticulum) stress inhibitor. BiP inducer X preferentially induces BiP with slight inductions of GRP94， calreticulin， and C/EBP homologous protein. BiP inducer X protects neurons from ER stress[1-2]. |
| In Vitro | BiP inducer X(5 μM; 12 hours; pretreatment with SK-N-SH cells)inhibits cell death induced by ER stress involving inhibited activation of caspases 3/7 and 4[1]. |
| In Vivo | A 20 μg portion of BiP inducer X administration reduces ER stress-induced apoptosis induced in the penumbra by MCA occlusion[1]. |
| Data Literature Source | [1]. Kudo T，et al. A molecular chaperone inducer protects neurons from ER stress. Cell Death Differ. 2008;15(2):364-375. [2]. Yoo SA，et al. A novel pathogenic role of the ER chaperone GRP78/BiP in rheumatoid arthritis. J Exp Med. 2012;209(4):871-886. |
| Unit | Bottle |
| Specification | 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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