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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Membrane Transporter & Ion Channel > AMG-9810CAS：545395-94-6
Molecular Formula：C21H23NO3
Molecular Weight：337.41
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥99%
Appearance：Light brown to brown Solid
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| CAS | 545395-94-6 |
| Name | AMG-9810 |
| Molecular Formula | C21H23NO3 |
| Molecular Weight | 337.41 |
| Solubility | Soluble in DMSO |
| Purity | ≥99% |
| Appearance | Light brown to brown Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00955103 |
| SMILES | CC(C)(C)C1=CC=C(C=C1)C=CC(=O)NC2=CC3=C(C=C2)OCCO3 |
| InChIKey | GZTFUVZVLYUPRG-IZZDOVSWSA-N |
| InChI | InChI=1S/C21H23NO3/c1-21(2，3)16-7-4-15(5-8-16)6-11-20(23)22-17-9-10-18-19(14-17)25-13-12-24-18/h4-11，14H，12-13H2，1-3H3，(H，22，23)/b11-6+ |
| PubChem CID | 680502 |
| Target Point | TRPV1 |
| Passage | Membrane Transporter&Ion Channel;Neuronal Signaling |
| Background | It is a selective and competitive vanillin receptor 1 (TRPV1) antagonist. |
| Biological Activity | AMG9810 是一种 TRPV1 拮抗剂，对人类和大鼠 TRPV1 的 IC50 值分别为 24.5 和 85.6 nM。[1-2] |
| IC50 | human TRPV1: 24.5nM(IC50);rat TRPV1:85.6nM(IC50)[1] |
| In Vitro | AMG 9810 is a competitive antagonist of capsaicin activation(IC50 value for human TRPV1，24.5 +/- 15.7 nM; rat TRPV1，85.6 +/- 39.4 nM)and blocks all known modes of TRPV1 activation，including protons(IC50 value for rat TRPV1，294 +/- 192 nM; human TRPV1，92.7 +/- 72.8 nM)，heat(IC50 value for rat TRPV1，21 +/- 17 nM; human TRPV1，15.8 +/- 10.8 nM)，and endogenous ligands，such as anandamide，N-arachidonyl dopamine，and oleoyldopamine.[1] |
| In Vivo | AMG 9810 is effective at preventing capsaicin-induced eye wiping in a dose-dependent manner，and it reverses thermal and mechanical hyperalgesia in a model of inflammatory pain induced by intraplantar injection of complete Freund's adjuvant.[1] AMG9810，promotes mouse skin tumorigenesis mediated through EGFR/Akt/mTOR signaling.[2] |
| Data Literature Source | [1]. Gavva NR，et al. AMG 9810 [(E)-3-(4-t-butylphenyl)-N-(2，3-dihydrobenzo[b][1，4] dioxin-6-yl)acrylamide]，a novel vanilloid receptor 1 (TRPV1) antagonist with antihyperalgesic properties. J Pharmacol Exp Ther. 2005 Apr;313(1):474-84. [2]. Li S，et al. TRPV1-antagonist AMG9810 promotes mouse skin tumorigenesis through EGFR/Akt signaling. Carcinogenesis. 2011 May;32(5):779-85. |
| Unit | Bottle |
| Specification | 5mg 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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