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My CartCAS：91296-86-5
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 91296-86-5 |
| Name | Difloxacin Hydrochloride |
| Molecular Formula | C21H20ClF2N3O3 |
| Molecular Weight | 435.85 |
| Solubility | Soluble in Water/DMSO(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD03840489 |
| SMILES | CN1CCN(CC1)C2=C(C=C3C(=C2)N(C=C(C3=O)C(=O)O)C4=CC=C(C=C4)F)F.Cl |
| InChIKey | JFMGBGLSDVIOHL-UHFFFAOYSA-N |
| InChI | InChI=1S/C21H19F2N3O3.ClH/c1-24-6-8-25(9-7-24)19-11-18-15(10-17(19)23)20(27)16(21(28)29)12-26(18)14-4-2-13(22)3-5-14;/h2-5，10-12H，6-9H2，1H3，(H，28，29);1H |
| PubChem CID | 56205 |
| Target Point | Bacterial |
| Passage | Anti-infection |
| Background | It is a broad-spectrum antibacterial compound that can inhibit bacterial DNA cyclase and show concentration-dependent bactericidal effect by interfering with the activity of DNA cyclase and topoisomerase IV. |
| Biological Activity | Difloxacin Hydrochloride 是一种广谱抗菌剂，可抑制细菌的 DNA 回旋酶，并通过干扰 DNA 回旋酶和拓扑异构酶 IV 的活性，表现出浓度依赖性杀菌效果。[1] |
| In Vivo | Administration of a therapeutic dose of difloxacin hydrochloride(10 mg/kg)is effective in the treatment of E. coli infection in chickens. The systemic bioavailability of difloxacin hydrochloride following oral administration was 86.2% in healthy chickens and 90.6% in E. coli-infected birds. The minimum inhibitory concentration(MIC)and the minimum bactericidal concentration(MBC)of difloxacin hydrochloride against the field strain of E. coli O78 in vitro were 0.02 μg and 0.04 μg/ml，respectively. The serum concentration of the drug was much higher than the MIC of the E. coli O78 strain in both healthy and infected chickens.[1] |
| Data Literature Source | [1]. Abo El-Ela FI，et al. Pharmacokinetics of difloxacin in healthy and E. coli-infected broiler chickens. Br Poult Sci. 2014;55(6):830-6. |
| Unit | Bottle |
| Specification | 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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