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My CartCAS：108433-99-4
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
Qty：
Size：
| CAS | 108433-99-4 |
| Name | Magainin 1 |
| Molecular Formula | C112H177N29O28S |
| Molecular Weight | 2409.85 |
| Solubility | Soluble in --- |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| SMILES | CC[C@H](C)[C@@H](C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC2=CN=CN2)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC3=CC=CC=C3)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CC4=CC=CC=C4)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)NC(=O)CN |
| InChIKey | OFIZOVDANLLTQD-ZVNXOKPXSA-N |
| InChI | InChI=1S/C112H177N29O28S/c1-12-65(7)93(139-86(144)54-117)110(166)122-59-89(147)128-75(39-25-29-46-115)100(156)135-81(51-70-33-19-15-20-34-70)105(161)133-79(49-63(3)4)104(160)136-83(53-72-55-118-62-123-72)106(162)137-84(60-142)108(164)124-67(9)95(151)119-56-87(145)127-74(38-24-28-45-114)99(155)134-80(50-69-31-17-14-18-32-69)97(153)120-57-88(146)126-73(37-23-27-44-113)98(154)125-68(10)96(152)132-82(52-71-35-21-16-22-36-71)107(163)140-92(64(5)6)109(165)121-58-90(148)129-77(41-42-91(149)150)103(159)141-94(66(8)13-2)111(167)131-78(43-48-170-11)102(158)130-76(40-26-30-47-116)101(157)138-85(61-143)112(168)169/h14-22，31-36，55，62-68，73-85，92-94，142-143H，12-13，23-30，37-54，56-61，113-117H2，1-11H3，(H，118，123)(H，119，151)(H，120，153)(H，121，165)(H，122，166)(H，124，164)(H，125，154)(H，126，146)(H，127，145)(H，128，147)(H，129，148)(H，130，158)(H，131，167)(H，132，152)(H，133，161)(H，134，155)(H，135，156)(H，136，160)(H，137，162)(H，138，157)(H，139，144)(H，140，163)(H，141，159)(H，149，150)(H，168，169)/t65-，66-，67-，68-，73-，74-，75-，76-，77-，78-，79-，80-，81-，82-，83-，84-，85-，92-，93-，94-/m0/s1 |
| PubChem CID | 16132169 |
| Target Point | Bacterial |
| Passage | Anti-infection |
| Background | It is an antibacterial and amphiphilic peptide that exhibits antibacterial activity against a variety of Gram-negative and Gram-positive bacteria. |
| Biological Activity | Magainin 1 是从爪蟾皮肤中分离出来的一种抗菌两亲肽，对多种革兰氏阴性和革兰氏阳性细菌具有抗菌活性。[1-2] |
| In Vitro | Magainin 1 induces the leakage of calcein specifically out of negatively-charged vesicles. Magainin 1 induces the leakage of calcein specifically out of negatively-charged vesicles. The peptide binds to bovine brain phosphatidylserine sonicated vesicles according to the Langmuir isotherm with a binding constant of 3.8.10(5)M-1 and a binding-site number of 0.10 per lipid molecule. Magainin 1 interacts with acidic lipids through electrostatic interactions followed by hydrophobic interactions to form an amphiphilic helix，inducing the leakage.[1] |
| Data Literature Source | [1]. Matsuzaki K，et al. Magainin 1-induced leakage of entrapped calcein out of negatively-charged lipid vesicles. Biochim Biophys Acta. 1989 May 19;981(1):130-4. [2]. Zasloff M. Magainins，a class of antimicrobial peptides from Xenopus skin: isolation，characterization of two active forms，and partial cDNA sequence of a precursor. Proc Natl Acad Sci U S A. 1987 Aug;84(15):5449-53. |
| Unit | Bottle |
| Specification | 1mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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