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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Membrane Transporter & Ion Channel > ML365CAS：947914-18-3
Molecular Formula：C22H20N2O3
Molecular Weight：360.41
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 947914-18-3 |
| Name | ML365 |
| Molecular Formula | C22H20N2O3 |
| Molecular Weight | 360.41 |
| Solubility | Soluble in DMSO(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| SMILES | CC1=CC(=CC=C1)C(=O)NC2=CC(=CC=C2)NC(=O)C3=CC=CC=C3OC |
| InChIKey | UTAJHKSGYJSZBR-UHFFFAOYSA-N |
| InChI | InChI=1S/C22H20N2O3/c1-15-7-5-8-16(13-15)21(25)23-17-9-6-10-18(14-17)24-22(26)19-11-3-4-12-20(19)27-2/h3-14H，1-2H3，(H，23，25)(H，24，26) |
| PubChem CID | 46785920 |
| Target Point | Potassium Channel (TASK1/KCNK3) |
| Passage | Membrane Transporter&Ion Channel |
| Background | ML365 is a selective 2-pore domain potassium channel TASK1/KCNK3 inhibitor. |
| Biological Activity | ML365 是 TASK1/KCNK3 的双孔域钾通道抑制剂，可作为探针，用于检查 TASK1 通道的特定作用。[1] |
| IC50 | TASK1/KCNK3: 4nM(IC50);TASK3/KCNK9: 390nM(IC50) [1] |
| In Vitro | ML365 blocks TASK1 channels in both the thallium influx fluorescent assay(IC50 = 4 nM)and an automated electrophysiology assay(IC50 = 16 nM). Based on potency differences，it possesses more than 60-fold selectivity for inhibition of TASK1 over a closely-related，two-pore domain potassium channel，TASK3. ML365 displays little or no inhibition at 30 μM of more distantly related potassium channels，Kir2.1，potassium voltage-gated channel，KQT-like subfamily，member 2(KCNQ2)，and human ether-a go-go-related gene(hERG).[1] |
| Data Literature Source | [1]. Zou B，et al. ML365: Development of Bis-Amides as Selective Inhibitors of the KCNK3/TASK1 Two Pore Potassium Channel. 2013 Apr 15 [updated 2013 Nov 14] |
| Unit | Bottle |
| Specification | 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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