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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Membrane Transporter & Ion Channel > Philanthotoxin 74 DihydrochlorideCAS：1227301-51-0
Molecular Formula：C24H44Cl2N4O3
Molecular Weight：507.54
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 1227301-51-0 |
| Name | Philanthotoxin 74 Dihydrochloride |
| Molecular Formula | C24H44Cl2N4O3 |
| Molecular Weight | 507.54 |
| Solubility | Soluble in Water/DMSO(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| SMILES | CCCC(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)NCCCCCCCNCCCCN.Cl.Cl |
| InChIKey | HWTJQQMIKVJWLH-IKXQUJFKSA-N |
| InChI | InChI=1S/C24H42N4O3.2ClH/c1-2-10-23(30)28-22(19-20-11-13-21(29)14-12-20)24(31)27-18-8-5-3-4-7-16-26-17-9-6-15-25;;/h11-14，22，26，29H，2-10，15-19，25H2，1H3，(H，27，31)(H，28，30);2*1H/t22-;;/m0../s1 |
| PubChem CID | 46213501 |
| Target Point | iGluR |
| Passage | Membrane Transporter&Ion Channel |
| Background | It is an antagonist to AMPAR. |
| Biological Activity | Philanthotoxin 74 dihydrochloride 是一种 AMPAR 拮抗剂，抑制 GluR3 和 GluR1 的 IC50 分别为 263 和 296 nM。[1] |
| IC50 | GluR1: 296nM(IC50)[1] |
| In Vitro | Philanthotoxin 74 Dihydrochloride(PhTX-74)inhibits homomeric GluA1 and GluA3 receptors nonselectively，with IC(50)values in the nanomolar range(252-356 nM)，and heteromeric GluA1/A2 and GluA2/A3 receptors nonselectively，with IC(50)values in the micromolar range(22 μM). PhTX-74 cannot pharmacologically discriminate between GluA2-containing AMPAR subtypes.[1] |
| Data Literature Source | [1]. Poulsen MH，et al. Evaluation of PhTX-74 as subtype-selective inhibitor of GluA2-containing AMPA receptors. Mol Pharmacol. 2014 Feb;85(2):261-8. |
| Unit | Bottle |
| Specification | 1mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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