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My CartCAS：84746-43-0
Storage：Powder:-20℃，1 year;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 84746-43-0 |
| Name | Small Cardioactive Peptide B |
| Molecular Formula | C52H80N14O11S2 |
| Molecular Weight | 1141.41 |
| Solubility | Soluble in Water(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:-20℃，1 year;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| SMILES | CC(C)CC(C(=O)NC(C)C(=O)NC(CC1=CC=CC=C1)C(=O)N2CCCC2C(=O)NC(CCCN=C(N)N)C(=O)NC(CCSC)C(=O)N)NC(=O)C(CC3=CC=C(C=C3)O)NC(=O)C(CC(=O)N)NC(=O)C(CCSC)N |
| InChIKey | IDATZUYVZKJKRE-SXMXEBDWSA-N |
| InChI | InChI=1S/C52H80N14O11S2/c1-29(2)25-37(63-48(74)38(26-32-15-17-33(67)18-16-32)64-49(75)39(28-42(54)68)62-45(71)34(53)19-23-78-4)47(73)59-30(3)44(70)65-40(27-31-11-7-6-8-12-31)51(77)66-22-10-14-41(66)50(76)61-36(13-9-21-58-52(56)57)46(72)60-35(43(55)69)20-24-79-5/h6-8，11-12，15-18，29-30，34-41，67H，9-10，13-14，19-28，53H2，1-5H3，(H2，54，68)(H2，55，69)(H，59，73)(H，60，72)(H，61，76)(H，62，71)(H，63，74)(H，64，75)(H，65，70)(H4，56，57，58)/t30-，34-，35-，36-，37-，38-，39-，40-，41-/m0/s1 |
| PubChem CID | 123843 |
| Target Point | Adenylate Cyclase |
| Passage | GPCR & G Protein |
| Background | It is a neuroactive peptide that stimulates adenylate cyclase activity in granular components of heart and gill tissue. |
| Biological Activity | Small Cardioactive Peptide B 是一种神经活性肽，能刺激心脏和鳃组织微粒馏分中腺苷酸环化酶的活性，其 EC50 值分别为 0.1 和 1.0 μM。[1] |
| In Vivo | Small cardioactive peptide B showed exert dose-dependent，reversible changes in cardiac activity when perfused through the isolated heart. The EC50 values effecting changes in heart rate and force of contraction were 3 X 10(-11)and 3 X 10(-10)M; minimum concentrations found to effect changes in heart rate and force of contraction were normally 10(-15)and 10(-12)M. When perfused through the isolated gill，small cardioactive peptide B suppressed the gill withdrawal response amplitude with a threshold concentration of 10(-14)M and an EC50 value of 3 X 10(-11)M. Suppression of the gill withdrawal response amplitude by small cardioactive peptide B was found to be dose dependent and reversible up to a concentration of 10(-9)M. At higher concentrations，the suppression tended to persist irreversibly. Small cardioactive peptide B stimulated adenylate cyclase activity in particulate fractions of both heart and gill tissues with an EC50 of 0.1 and 1.0 microM，respectively.[1] |
| Data Literature Source | [1]. Cawthorpe DR，et al. The effects of small cardioactive peptide B on the isolated heart and gill of Aplysia californica. Can J Physiol Pharmacol. 1985 Aug;63(8):918-24. |
| Unit | Bottle |
| Specification | 1mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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