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My CartCAS：229971-81-7
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 229971-81-7 |
| Name | ADH-1 |
| Molecular Formula | C22H34N8O6S2 |
| Molecular Weight | 570.69 |
| Solubility | Soluble in DMSO(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD18251730 |
| SMILES | CC1C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)N1)CC2=CN=CN2)NC(=O)C)C(=O)N)C(C)C |
| InChIKey | FQVLRGLGWNWPSS-BXBUPLCLSA-N |
| InChI | InChI=1S/C22H34N8O6S2/c1-10(2)17-22(36)29-15(18(23)32)7-37-38-8-16(27-12(4)31)21(35)28-14(5-13-6-24-9-25-13)20(34)26-11(3)19(33)30-17/h6，9-11，14-17H，5，7-8H2，1-4H3，(H2，23，32)(H，24，25)(H，26，34)(H，27，31)(H，28，35)(H，29，36)(H，30，33)/t11-，14-，15-，16-，17-/m0/s1 |
| PubChem CID | 9916058 |
| Target Point | N-cadherin |
| Passage | Others |
| Background | It is a selective and competitive N-cadherin antagonist. |
| Biological Activity | ADH-1 是一种 N-粘连蛋白拮抗剂，可抑制 N-粘连蛋白介导的细胞粘附。[1-3] |
| In Vitro | ADH-1 induced apoptosis in a concentration dependent and N-cadherin dependent manner in pancreatic cancer cells.[1] Cytotoxic activity in human umbilical vein endothelial cells，PC3，and Tsu-Pr1 cells，when ADH1 exposure was evaluated at 500 micromol/l or above.[2] |
| In Vivo | ADH-1 treatment resulted in significant reductions in tumor growth and lung metastasis in a mouse model for pancreatic cancer.[1] ADH-1 increased vascular permeability without effecting tumor interstitial fluid pressure，leading to increased delivery of LPAM but not TMZ.[3] |
| Data Literature Source | [1]. Shintani Y，et al. ADH-1 suppresses N-cadherin-dependent pancreatic cancer progression. Int J Cancer. 2008 Jan 1;122(1):71-7. [2]. Li H，et al. ADH1，an N-cadherin inhibitor，evaluated in preclinical models of angiogenesis and androgen-independent prostate cancer. Anticancer Drugs. 2007 Jun;18(5):563-8. [3]. Turley RS，et al. Targeting N-cadherin increases vascular permeability and differentially activates AKT in melanoma. Ann Surg. 2015 Feb;261(2):368-77. |
| Unit | Bottle |
| Specification | 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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