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My CartCAS：1135237-88-5
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 1135237-88-5 |
| Name | ADH-1 Trifluoroacetate |
| Molecular Formula | C24H35F3N8O8S2 |
| Molecular Weight | 684.71 |
| Solubility | Soluble in DMSO(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| SMILES | C[C@H]1C(=O)N[C@H](C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@H](C(=O)N1)CC2=CN=CN2)NC(=O)C)C(=O)N)C(C)C.C(=O)(C(F)(F)F)O |
| InChIKey | RMLOJFSXNMROLS-BMLUHVGESA-N |
| InChI | InChI=1S/C22H34N8O6S2.C2HF3O2/c1-10(2)17-22(36)29-15(18(23)32)7-37-38-8-16(27-12(4)31)21(35)28-14(5-13-6-24-9-25-13)20(34)26-11(3)19(33)30-17;3-2(4，5)1(6)7/h6，9-11，14-17H，5，7-8H2，1-4H3，(H2，23，32)(H，24，25)(H，26，34)(H，27，31)(H，28，35)(H，29，36)(H，30，33);(H，6，7)/t11-，14-，15-，16-，17-;/m0./s1 |
| PubChem CID | 24203776 |
| Target Point | N-cadherin |
| Passage | Others |
| Background | It is a selective and competitive N-cadherin antagonist. |
| Biological Activity | ADH-1 Trifluoroacetate 是一种 N-粘连蛋白拮抗剂，可抑制 N-粘连蛋白介导的细胞粘附。[1-3] |
| In Vitro | ADH-1 trifluoroacetate induced apoptosis in a concentration dependent and N-cadherin dependent manner in pancreatic cancer cells.[1] The cytotoxic activity has been detected in human umbilical vein endothelial cells，PC3，and Tsu-Pr1 cells，when ADH1 exposure was evaluated at 500 micromol/l or above.[2] |
| In Vivo | ADH-1 trifluoroacetate treatment resulted in significant reductions in tumor growth and lung metastasis in a mouse model for pancreatic cancer.[1] Combination of ADH-1 with TMZ ILI did not improve tumor response in A375 tumors. ADH-1 increased vascular permeability without effecting tumor interstitial fluid pressure，leading to increased delivery of LPAM but not TMZ.[3] |
| Data Literature Source | [1]. Shintani Y，et al. ADH-1 suppresses N-cadherin-dependent pancreatic cancer progression. Int J Cancer. 2008 Jan 1;122(1):71-7. [2]. Li H，Price DK，et al. ADH1，an N-cadherin inhibitor，evaluated in preclinical models of angiogenesis and androgen-independent prostate cancer. Anticancer Drugs. 2007 Jun;18(5):563-8. [3]. Turley RS，et al. Targeting N-cadherin increases vascular permeability and differentially activates AKT in melanoma. Ann Surg. 2015 Feb;261(2):368-77. |
| Unit | Bottle |
| Specification | 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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