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My CartCAS：59338-87-3
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 59338-87-3 |
| Name | Alizapride Hydrochloride |
| Molecular Formula | C16H22ClN5O2 |
| Molecular Weight | 351.83 |
| Solubility | Soluble in Water/DMSO(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD02183928 |
| SMILES | COC1=CC2=C(C=C1C(=O)NCC3CCCN3CC=C)NN=N2.Cl |
| InChIKey | BRECEDGYMYXGNF-UHFFFAOYSA-N |
| InChI | InChI=1S/C16H21N5O2.ClH/c1-3-6-21-7-4-5-11(21)10-17-16(22)12-8-13-14(19-20-18-13)9-15(12)23-2;/h3，8-9，11H，1，4-7，10H2，2H3，(H，17，22)(H，18，19，20);1H |
| PubChem CID | 135497066 |
| Target Point | Dopamine Receptor |
| Passage | Neuronal Signaling;GPCR & G Protein |
| Background | Alizapride hydrochloride is a dopamine receptor antagonist with motion-promoting and antiemetic activity. |
| Biological Activity | Alizapride Hydrochloride 是一种含有 N-烯丙基的多巴胺拮抗剂，促肠胃运动和具有止吐特性。[1-2] |
| In Vitro | 盐酸阿立必利在 N-脱烯丙基氧化过程中会形成丙烯醛，以及环氧化物代谢物的形成。[1] |
| In Vivo | D2受体拮抗剂阿立必利(均为 5 毫克/千克，静脉注射)促进大鼠胃肠蠕动。[2] |
| Data Literature Source | [1]. Aprile S，et al. In vitro metabolic fate of alizapride: evidence for the formation of reactive metabolites based on liquid chromatography-tandem mass spectrometry. J Mass Spectrom. 2012 Jun;47(6):737-50. [2]. Dhasmana KM，et al. The role of dopamine (D2)，alpha and beta-adrenoceptor receptors in the decrease in gastrointestinal transit induced by dopamine and dopamine-related drugs in the rat. Pharmacol Res. 1993 May-Jun;27(4):335-47. |
| Unit | Bottle |
| Specification | 25mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
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