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My CartCAS：139110-80-8
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
Qty：
Size：
| CAS | 139110-80-8 |
| Name | Zanamivir |
| Molecular Formula | C12H20N4O7 |
| Molecular Weight | 332.31 |
| Solubility | Soluble in Water(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00866966 |
| SMILES | CC(=O)N[C@@H]1[C@H](C=C(O[C@H]1[C@@H]([C@@H](CO)O)O)C(=O)O)N=C(N)N |
| InChIKey | ARAIBEBZBOPLMB-UFGQHTETSA-N |
| InChI | InChI=1S/C12H20N4O7/c1-4(18)15-8-5(16-12(13)14)2-7(11(21)22)23-10(8)9(20)6(19)3-17/h2，5-6，8-10，17，19-20H，3H2，1H3，(H，15，18)(H，21，22)(H4，13，14，16)/t5-，6+，8+，9+，10+/m0/s1 |
| PubChem CID | 60855 |
| Target Point | Influenza Virus |
| Passage | Anti-infection |
| Background | Zanamivir is a neuraminidase inhibitor of influenza virus with anti-influenza activity. |
| Biological Activity | Zanamivir 是流感病毒的神经氨酸酶抑制剂，对于流感病毒 A 和 B 的IC50值分别为 0.95 nM 和 2.7 nM。[1] |
| IC50 | Influenza A: 0.95nM(IC50);Influenza B: 2.7nM(IC50)[1] |
| In Vitro | Zanamivir，a novel neuraminidase inhibitor，is effective at decreasing replication of the virus in vitro. [2] His274Asn，as well as His274Gly，His274Ser，and His274Gln，also displayed reduced sensitivity to zanamivir and its analogue，4-amino-Neu5Ac2en. [3] In HPF3，zanamivir and its analogs have an affinity not only for the neuraminidase active site of HN but also for sites important for receptor binding and cell fusion.[4] |
| In Vivo | Zanamivir，a novel neuraminidase inhibitor，is effective at decreasing replication of the virus in vitro. In a model of lethal challenge in mice，zanamivir reduces lung titers of the virus and decreases morbidity and mortality.[2] |
| Data Literature Source | [1]. Gubareva LV，et al. Comparison of the activities of zanamivir，oseltamivir，and RWJ-270201 against clinical isolates of influenza virus and neuraminidase inhibitor-resistant variants. Antimicrob Agents Chemother. 2001 Dec;45(12):3403-8. [2]. Gubareva LV，et al. Characterization of influenza A/HongKong/156/97 (H5N1) virus in a mouse model and protective effect of zanamivir on H5N1 infection in mice. J Infect Dis. 1998 Dec;178(6):1592-6. [3]. Wang MZ，et al. Mechanism by which mutations at his274 alter sensitivity of influenza a virus n1 neuraminidase to oseltamivir carboxylate and zanamivir. Antimicrob Agents Chemother. 2002 Dec;46(12):3809-16. [4]. Greengard O，et al. The anti-influenza virus agent 4-GU-DANA (zanamivir) inhibits cell fusion mediated by human parainfluenza virus and influenza virus HA. J Virol. 2000 Dec;74(23):11108-14. |
| Unit | Bottle |
| Specification | 5mg 10mg 20mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
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2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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