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My CartCAS：133868-46-9
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
Qty：
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| CAS | 133868-46-9 |
| Name | Valnemulin Hydrochloride |
| Molecular Formula | C31H53ClN2O5S |
| Molecular Weight | 601.28 |
| Solubility | Soluble in Water/DMSO(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD08458958 |
| SMILES | C[C@@H]1CC[C@@]23CCC(=O)[C@H]2[C@@]1([C@@H](C[C@@]([C@H]([C@@H]3C)O)(C)C=C)OC(=O)CSC(C)(C)CNC(=O)[C@@H](C(C)C)N)C.Cl |
| InChIKey | MFBPRQKHDIVLOJ-AFFLPQGKSA-N |
| InChI | InChI=1S/C31H52N2O5S.ClH/c1-10-29(8)15-22(38-23(35)16-39-28(6，7)17-33-27(37)24(32)18(2)3)30(9)19(4)11-13-31(20(5)26(29)36)14-12-21(34)25(30)31;/h10，18-20，22，24-26，36H，1，11-17，32H2，2-9H3，(H，33，37);1H/t19-，20+，22-，24-，25+，26+，29-，30+，31+;/m1./s1 |
| PubChem CID | 60195218 |
| Target Point | Bacterial |
| Passage | Anti-infection |
| Background | It is an antibiotic that inhibits protein synthesis in bacteria by binding to peptidyl transferase in the 50s ribosome subunit. |
| Biological Activity | Valnemulin Hydrochloride 是一种胸腺嘧啶类抗生素，是肽基转移酶的强抑制剂，通过结合 50s 核糖体亚基中的肽基转移酶来抑制细菌的蛋白质合成。[1-3] |
| In Vitro | 胸腺嘧啶抗生素衍生物盐酸沃尼妙林可与细菌的 50S 核糖体亚基结合，从而抑制蛋白质合成。盐酸沃尼妙林是肽基转移酶的强抑制剂，并与 23S RNA 的第 V 结构域相互作用，在核苷酸 A2058-9、U2506 和 U2584-5 上留下了清晰的化学足迹[1]。盐酸沃尼妙林对肺炎链球菌(MIC90 为 0.0005 微克毫升-1)和肺炎链球菌(MIC 范围为 0.0001 微克毫升-1 至 0.00025 微克毫升-1)的野外菌株显示出卓越的活性[2]。 |
| In Vivo | 盐酸沃尼妙林对 LPS 诱导的小鼠 ALI 有保护作用。在脂多糖(LPS)诱导的小鼠炎症性肺损伤模型中，盐酸沃尼妙林(100 毫克/千克)显著提高 LPS 诱导的 BALF 中的 SOD 活性，并降低肺 MPO 活性。盐酸沃尼妙林抑制肿瘤坏死因子-α、白细胞介素-6 和白细胞介素-1beta 的产生。[3] |
| Data Literature Source | [1]. Poulsen SM，et al. The pleuromutilin drugs tiamulin and valnemulin bind to the RNA at the peptidyl transferase centre on the ribosome. Mol Microbiol. 2001 Sep;41(5):1091-9. [2]. Hannan PC，et al. In vitro susceptibilities of recent field isolates of Mycoplasma hyopneumoniae and Mycoplasma hyosynoviae to valnemulin (Econor)，tiamulin and enrofloxacin and the in vitro development of resistance to certain antimicrobial agents in Mycoplasma hyopneumoniae. Res Vet Sci. 1997 Sep-Oct;63(2):157-60. [3]. Chen Z，et al. Preventive effects of valnemulin on lipopolysaccharide-induced acute lung injury in mice. Inflammation. 2010 Oct;33(5):306-14. |
| Unit | Bottle |
| Specification | 10mg 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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