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My CartCAS：173903-47-4
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Light yellow to yellow Solid
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| CAS | 173903-47-4 |
| Name | Tizoxanide |
| Molecular Formula | C10H7N3O4S |
| Molecular Weight | 265.25 |
| Solubility | Soluble in DMSO(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD07484970 |
| SMILES | C1=CC=C(C(=C1)C(=O)NC2=NC=C(S2)[N+](=O)[O-])O |
| InChIKey | FDTZUTSGGSRHQF-UHFFFAOYSA-N |
| InChI | InChI=1S/C10H7N3O4S/c14-7-4-2-1-3-6(7)9(15)12-10-11-5-8(18-10)13(16)17/h1-5，14H，(H，11，12，15) |
| PubChem CID | 394397 |
| Target Point | Bacterial;Parasite;HIV;HBV;HCV |
| Passage | Anti-infection |
| Background | It is a thiazolamine antibiotic, with anti-anaerobic bacteria, antigenic animals and antiviral activities. |
| Biological Activity | Tizoxanide 是 Nitazoxanide 的主要活性代谢产物，具有抗 HIV-1 活性，对 HBV 和 HCV 的复制具有强效抑制作用，其 EC50 值分别为 0.46μM 和 0.15μM。抑制促炎细胞因子的产生，抑制 LPS 处理的巨噬细胞中 NF-κB 和 MAPK 信号通路的激活。[1-4] |
| In Vitro | 硝唑尼特及其代谢物替唑尼特可诱导线粒体轻度解偶联，随后激活HepG2细胞中的AMPK。[1] 硝唑尼特及其主要代谢产物替唑尼特能抑制丙型肝炎病毒(HCV)在HCV复制子系统中的复制。将携带 HCV 复制子的 Huh7 细胞放入这替唑尼特中，会导致替唑尼特的 50%有效浓度(EC(50)s)(7 至 13 倍)、EC(90)s(14 至 36 倍)和 50%细胞毒性浓度(2 至 4 倍)增加。[2] 替唑尼特对乙型肝炎病毒(HBV)和丙型肝炎病毒(HCV)的复制都有很强的抑制作用。[3]替唑尼特可抑制促炎细胞因子的产生，抑制 LPS 处理的巨噬细胞中 NF-κB 和 MAPK 信号通路的激活，从而发挥抗炎作用。[4] |
| In Vivo | 在大鼠身上进行的应用表明，服用 10 毫克/千克硝唑沙尼后 1 小时内，脑血浆中的硝唑沙尼比例为 3.16% 至 26.86%。[5] |
| Data Literature Source | [1]. Li F，et al. Anthelmintics nitazoxanide protects against experimental hyperlipidemia and hepatic steatosis in hamsters and mice. Acta Pharm Sin B. 2022 Mar;12(3):1322-1338. [2]. Korba BE，et al. Potential for hepatitis C virus resistance to nitazoxanide or tizoxanide. Antimicrob Agents Chemother. 2008 Nov;52(11):4069-71. [3]. Korba BE，et al. Nitazoxanide，tizoxanide and other thiazolides are potent inhibitors of hepatitis B virus and hepatitis C virus replication. Antiviral Res. 2008 Jan;77(1):56-63. [4]. Shou J，et al. Tizoxanide Inhibits Inflammation in LPS-Activated RAW264.7 Macrophages via the Suppression of NF-κB and MAPK Activation. Inflammation. 2019 Aug;42(4):1336-1349. [5]. Guo S，et al. Analysis of tizoxanide，active metabolite of nitazoxanide，in rat brain tissue and plasma by UHPLC-MS/MS. Biomed Chromatogr. 2020 Feb;34(2):e4716. |
| Unit | Bottle |
| Specification | 10mg |
是一种噻唑胺类抗生素，对厌氧菌、原生动物和一系列病毒产生作用。具有抗 HIV-1活性，对 HBV 和 HCV 的复制有较强的抑制作用。还通过抑制 LPS 处理的巨噬细胞中促炎细胞因子的产生和 NF-κB 以及 MAPK 信号通路的激活发挥抗炎作用。
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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