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My CartCAS：328898-40-4
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 328898-40-4 |
| Name | Tildipirosin |
| Molecular Formula | C41H71N3O8 |
| Molecular Weight | 734.02 |
| Solubility | Soluble in DMSO ≥10mg/mL |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD13194925 |
| SMILES | CCC1C(C=C(C=CC(=O)C(CC(C(C(C(CC(=O)O1)O)C)OC2C(C(C(C(O2)C)O)N(C)C)O)CCN3CCCCC3)C)C)CN4CCCCC4 |
| InChIKey | HNDXPZPJZGTJLJ-UEJFNEDBSA-N |
| InChI | InChI=1S/C41H71N3O8/c1-8-35-32(26-44-20-13-10-14-21-44)23-27(2)15-16-33(45)28(3)24-31(17-22-43-18-11-9-12-19-43)40(29(4)34(46)25-36(47)51-35)52-41-39(49)37(42(6)7)38(48)30(5)50-41/h15-16，23，28-32，34-35，37-41，46，48-49H，8-14，17-22，24-26H2，1-7H3/b16-15+，27-23+/t28-，29+，30-，31+，32-，34-，35-，37+，38-，39-，40-，41+/m1/s1 |
| PubChem CID | 24860548 |
| Target Point | Bacterial |
| Passage | Anti-infection |
| Background | Tildipirosin is a macrocyclic lipid antibiotic. |
| Biological Activity | Tildipirosin 是一种半合成的大环内酯物质，具有抗菌的功效。[1] |
| In Vitro | Tildipirosin(TIP)A decrease in pH from 7.3 to 6.7 resulted in an increase in MICs of tildipirosin(TIP). Except for the MICs > 256 μg/mL observed in the resistant subpopulation of the C. coli and the Enterococcus species，the MIC ranges increased from 2-8 μg/mL to 64-> 256 μg/mL for Salmonella enterica and E. coli，from 8-16 μg/mL to 32-128 μg/mL for the two Campylobacter species，and from 4-32 μg/mL to 128-> 256 μg/mL for both Enterococcus species.[1] The treponeme phylogroups T. medium/T. vincentii-like，T. phagedenis-like and T. pedis tested showed low MICs and MBCs to all 10 antimicrobials tested. They were susceptible to tildipirosin(MIC90: 0.0469 mg/L).[2] |
| In Vivo | Metaphylactic administration of tildipirosin to calves 5 days prior to H somni challenge prevented subsequent culture of the pathogen from bronchial secretions and was more effective in minimizing clinical disease and lung lesions than was metaphylactic administration of tulathromycin.[3] |
| Animal Experiment | Calves were randomly allocated to 3 groups of 8 calves. On day 0，calves in group 1 received tildipirosin(4 mg/kg，SC)，calves in group 2 received tulathromycin(2.5 mg/kg，SC)，and calves in group 3 received isotonic saline(0.9% NaCl)solution(1 mL/45 kg，SC; control). On day 5，calves were inoculated with 10 mL of a solution containing H somni strain 7735(1.6 × 10(9)CFUs/mL，intrabronchially; challenge). Calves were clinically evaluated on days 5 through 8 and euthanized on day 8. The lungs were grossly evaluated for evidence of pneumonia，and bronchial secretion samples underwent bacteriologic culture.[3] |
| Data Literature Source | [1]. Rose M，et al. A microbiological assay to estimate the antimicrobial activity of parenteral tildipirosin against foodborne pathogens and commensals in the colon of beef cattle and pigs. J Vet Pharmacol Ther. 2016 Jun;39(3):277-86. [2]. Angell JW，et al. In vitro susceptibility of contagious ovine digital dermatitis associated Treponema spp. isolates to antimicrobial agents in the UK. Vet Dermatol. 2015 Dec;26(6):484-7，e114-5. [3]. Confer AW，et al. Clinical disease and lung lesions in calves experimentally inoculated with Histophilus somni five days after metaphylactic administration of tildipirosin or tulathromycin. Am J Vet Res. 2016 Apr;77(4):358-66. |
| Unit | Bottle |
| Specification | 1mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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