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My CartCAS：63-74-1
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 63-74-1 |
| Name | Sulfanilamide |
| Molecular Formula | C6H8N2O2S |
| Molecular Weight | 172.2 |
| Solubility | Soluble in DMSO(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 200-563-4 |
| MDL | MFCD00007939 |
| SMILES | C1=CC(=CC=C1N)S(=O)(=O)N |
| InChIKey | FDDDEECHVMSUSB-UHFFFAOYSA-N |
| InChI | InChI=1S/C6H8N2O2S/c7-5-1-3-6(4-2-5)11(8，9)10/h1-4H，7H2，(H2，8，9，10) |
| PubChem CID | 5333 |
| Target Point | Bacterial |
| Passage | Anti-infection |
| Background | Sulfanilamide is a competing inhibitor of the synthesis of dihydrotrexate in bacterial enzymes. |
| Biological Activity | Sulfanilamide 是细菌酶中二氢喋呤合成的适度竞争性抑制剂，是一种有效的口服磺胺类抗生素，是磺胺甲恶唑生物降解的主要中间体，可预防卡氏肺孢子虫和肺炎病菌感染。[1-4] |
| In Vitro | At the initial sulfanilamide concentration of 100 μg/L，nearly half of the antibiotic could be removed by acclimated microbial populations after 1 week of incubation，and an average removal rate of 78.3 % could be achieved in 4 weeks. Sulfanilamide biodegradation could be enhanced by a temperature rise and the presence of external carbon or nitrogen sources.Firmicutes and Bacteroidetes(mainly represented by classes Bacilli and Flavobacteriia)dominated the sulfanilamide-degrading bacterial community.[1] |
| In Vivo | Albino mice inoculated intranasally or intraperitoneally with 51. pneumoniae，strain 444. Sulfadimesin and domian，2 sulfanilamides of short action served as the control. The drugs were administered orally in a dose of 500 mg/kg daily for 5 days. High efficacy of the sulfanilamide depots in the treatment of the 51. pneumoniae infected mice and low activity of the short-action drugs were shown.High efficacy of the sulfanilamide depots in the treatment of the 51. pneumoniae infected mice and low activity of the short-action drugs were shown，which was confirmed by the data of the pathomorphological investigation in experimental pneumonia.[2]With the immunosuppressed rat model，P. carinii infection was prevented in all animals(100%)receiving 100 mg of sulfanilamide per kg per day. [3] |
| Data Literature Source | [1]. Liao X，et al. Antibiotic sulfanilamide biodegradation by acclimated microbial populations. Appl Microbiol Biotechnol. 2016 Mar;100(5):2439-47. [2]. Pade skaia EN，et al. Sravnitel'naia aktivnost' depo-sul'fanilamidov pri éksperimental'no infektsii myshe ，vyzvanno K1. pneumoniae [Comparative activity of depot sulfanilamides in experimental infection in mice caused by K1. pneumoniae]. Antibiotiki. 1980 Mar;25(3):193-8. [3]. Hughes WT，et al. Monodrug efficacies of sulfonamides in prophylaxis for Pneumocystis carinii pneumonia. Antimicrob Agents Chemother. 1996 Apr;40(4):962-5. [4]. McCullough JL，et al. Inhibition of dihydropteroate synthetase from Escherichia coli by sulfones and sulfonamides. Antimicrob Agents Chemother. 1973 Jun;3(6):665-9. |
| Unit | Bottle |
| Specification | 500mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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