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My CartCAS：144-82-1
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 144-82-1 |
| Name | Sulfamethizole |
| Molecular Formula | C9H10N4O2S2 |
| Molecular Weight | 270.33 |
| Solubility | Soluble in DMSO ≥5mg/mL |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 205-641-1 |
| MDL | MFCD00053363 |
| SMILES | CC1=NN=C(S1)NS(=O)(=O)C2=CC=C(C=C2)N |
| InChIKey | VACCAVUAMIDAGB-UHFFFAOYSA-N |
| InChI | InChI=1S/C9H10N4O2S2/c1-6-11-12-9(16-6)13-17(14，15)8-4-2-7(10)3-5-8/h2-5H，10H2，1H3，(H，12，13) |
| PubChem CID | 5328 |
| Target Point | Bacterial |
| Passage | Anti-infection |
| Background | Sulfamethizole is a sulfamethizole antibiotic that inhibits PABA in bacteria. |
| Biological Activity | Sulfamethizole 是一种磺胺噻唑类抗菌剂，一种二氢蝶酸合成酶和叶酸形成的抑制剂。[1-2] |
| In Vitro | 磺胺甲二唑对生物发光的抑制作用大于对生长的抑制作用。 [1] |
| In Vivo | 尿毒症小鼠用磺胺甲二唑处理后，易感菌株(MIC：128 微克/毫升)和耐药菌株(MIC：512 微克/毫升)的所有样本中的细菌数量都明显减少。磺胺甲二唑不能治疗 sulII 基因阳性菌株(MIC 值大于 2，048 微克/毫升)的感染。 |
| Data Literature Source | [1]. Watanabe H，et al. Inhibition of bioluminescence in Photobacterium phosphoreum by sulfamethizole and its stimulation by thymine. Biochim Biophys Acta. 1990 Jun 26;1017(3):229-34. [2]. Kerrn MB，et al. Effects of sulfamethizole and amdinocillin against Escherichia coli strains (with various susceptibilities) in an ascending urinary tract infection mouse model. Antimicrob Agents Chemother. 2003 Mar;47(3):1002-9. |
| Unit | Bottle |
| Specification | 500mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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