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My CartCAS：89365-50-4
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 89365-50-4 |
| Name | Salmeterol |
| Molecular Formula | C25H37NO4 |
| Molecular Weight | 415.57 |
| Solubility | Soluble in DMSO(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00867037 |
| SMILES | C1=CC=C(C=C1)CCCCOCCCCCCNCC(C2=CC(=C(C=C2)O)CO)O |
| InChIKey | GIIZNNXWQWCKIB-UHFFFAOYSA-N |
| InChI | InChI=1S/C25H37NO4/c27-20-23-18-22(13-14-24(23)28)25(29)19-26-15-7-1-2-8-16-30-17-9-6-12-21-10-4-3-5-11-21/h3-5，10-11，13-14，18，25-29H，1-2，6-9，12，15-17，19-20H2 |
| PubChem CID | 5152 |
| Target Point | Adrenergic Receptor |
| Passage | Endocrinology & Hormones;GPCR & G Protein；Neuronal Signaling |
| Background | It is a potent and selective beta-2 adrenergic receptor agonist. |
| Biological Activity | Salmeterol 是一种强效、选择性的人类 β2 肾上腺素受体激动剂。能有效刺激 cAMP 的积累，在表达人 β2、β1 和 β3 肾上腺素受体的 CHO 细胞中，pEC50s 分别为 9.6、6.1 和 5.9。[1] |
| In Vitro | 沙美特罗(0.001-25 μM)抑制人 T 淋巴细胞增殖。[2] |
| In Vivo | 沙美特罗(0.16 mg/kg)和福莫特罗(0.32 mg/kg)对慢性阻塞性肺病小鼠的气道和血管重塑有益。[3] |
| Data Literature Source | [1]. Procopiou PA，et al. The discovery of long-acting saligenin β adrenergic receptor agonists incorporating a urea group. Bioorg Med Chem. 2011 Oct 15;19(20):6026-32. [2]. Johnson M. Effects of beta2-agonists on resident and infiltrating inflammatory cells. J Allergy Clin Immunol. 2002 Dec;110(6 Suppl):S282-90. [3]. Wang Z，Wang C，Yang X. Efficacy of salmeterol and formoterol combination treatment in mice with chronic obstructive pulmonary disease. Exp Ther Med. 2018 Feb;15(2):1538-1545. |
| Unit | Bottle |
| Specification | 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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