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My CartCAS：25875-50-7
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 25875-50-7 |
| Name | Robenidine Hydrochoride |
| Molecular Formula | C15H14Cl3N5 |
| Molecular Weight | 370.66 |
| Solubility | Soluble in DMSO(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 247-307-8 |
| MDL | MFCD01724404 |
| SMILES | C1=CC(=CC=C1C=NNC(=NN=CC2=CC=C(C=C2)Cl)N)Cl.Cl |
| InChIKey | LTWIBTYLSRDGHP-HCURTGQUSA-N |
| InChI | InChI=1S/C15H13Cl2N5.ClH/c16-13-5-1-11(2-6-13)9-19-21-15(18)22-20-10-12-3-7-14(17)8-4-12;/h1-10H，(H3，18，21，22);1H/b19-9+，20-10+; |
| PubChem CID | 16212175 |
| Target Point | Parasite |
| Passage | Anti-infection |
| Background | It is a compound with anticoccidioid activity and also has inhibitory activity against MRSA and VRE. |
| Biological Activity | Robenidine hydrochloride 是一种抗球虫药，对 MRSA 和 VRE 也有抑制活性，其 MIC50 值分别为 8.1 和 4.7 μM。[1] |
| In Vitro | 盐酸氯苯胍对 MRSA 和 VRE 有活性，其 MIC 值分别为 8.1 和 4.7 μM。盐酸氯苯胍在人和小鼠脂质体中均显示出极佳的微粒体稳定性、内在清除率和肝萃取率，T1/2 > 247 分钟，CLint < 7 μL/min/mg 蛋白质。[1] |
| In Vivo | 对兔子进行了一次静脉注射氟苯尼考(25 毫克/千克)后，分别喂食不含抗球虫药物的饲料或盐酸氯苯胍(百万分之 66)的饲料 20 天，与不含抗球虫药物的喂养相比，盐酸氯苯胍喂养导致血浆氟苯尼考水平明显下降。盐酸氯苯胍预处理兔的末端消除半衰期(t1/2z)、浓度-时间曲线下面积(AUC)、第一矩曲线下面积(AUMC)和平均停留时间(MRT)明显下降，而消除速率常数(λz)和全身清除率(CLz)明显增加。[2] |
| Data Literature Source | [1]. Abraham RJ，et al. Robenidine Analogues as Gram-Positive Antibacterial Agents. J Med Chem. 2016 Mar 10;59(5):2126-38. [2]. Liu C，et al. Influence of three coccidiostats on the pharmacokinetics of florfenicol in rabbits. Exp Anim. 2015;64(1):73-9. doi: 10.1538/expanim.14-0064. Epub 2014 Oct 16. |
| Unit | Bottle |
| Specification | 25mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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