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My CartCAS：53797-35-6
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 53797-35-6 |
| Name | Ribostamycin Sulfate |
| Molecular Formula | C17H36N4O14S |
| Molecular Weight | 552.55 |
| Solubility | Soluble in Water ≥10mg/mL |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 258-783-1 |
| MDL | MFCD23380549 |
| SMILES | C1C(C(C(C(C1N)OC2C(C(C(C(O2)CN)O)O)N)OC3C(C(C(O3)CO)O)O)O)N.OS(=O)(=O)O |
| InChIKey | RTCDDYYZMGGHOE-YMSVYGIHSA-N |
| InChI | InChI=1S/C17H34N4O10.H2O4S/c18-2-6-10(24)12(26)8(21)16(28-6)30-14-5(20)1-4(19)9(23)15(14)31-17-13(27)11(25)7(3-22)29-17;1-5(2，3)4/h4-17，22-27H，1-3，18-21H2;(H2，1，2，3，4)/t4-，5+，6-，7-，8-，9+，10-，11-，12-，13-，14-，15-，16-，17+;/m1./s1 |
| PubChem CID | 656837 |
| Target Point | Bacterial |
| Passage | Anti-infection |
| Background | It is an aminoglycoside antibiotic with broad-spectrum antibacterial activity and inhibits bacterial protein synthesis at 30S and 50S ribosomal subunit binding levels. |
| Biological Activity | Ribostamycin Sulfate）是一种广谱抗菌药，可在 30S 和 50S 核糖体亚基结合水平上抑制细菌蛋白质合成，还可抑制蛋白二硫异构酶 (PDI) 的伴侣活性，用于药代动力学和肾毒性研究。[1-3] |
| In Vitro | 硫酸核糖霉素是新霉素生物合成过程中的中间体。[1]硫酸核糖霉素抑制鲍瑞菌的MIC(90)值为32 毫克/升)。[2]硫酸核糖霉素能抑制蛋白二硫异构酶(PDI)的伴侣活性，但不能抑制异构酶的活性。硫酸核糖霉素与 PDI 的摩尔比为 100:1，几乎足以完全抑制 PDI 的合酶活性，其 K(D)值为 3.19 x 10(-4)M。[3] |
| Data Literature Source | [1]. Baud H，et al. Ribostamycin，as an intermediate in the biosynthesis of neomycin. J Antibiot (Tokyo). 1977 Sep;30(9):720-3. [2]. Hunfeld KP，et al. In vitro activity of mezlocillin，meropenem，aztreonam，vancomycin，teicoplanin，ribostamycin and fusidic acid against Borrelia burgdorferi. Int J Antimicrob Agents. 2001 Mar;17(3):203-8. [3]. Horibe T，et al. Ribostamycin inhibits the chaperone activity of protein disulfide isomerase. Biochem Biophys Res Commun. 2001 Dec 21;289(5):967-72. |
| Unit | Bottle |
| Specification | 25mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
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