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My CartCAS：224452-66-8
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 224452-66-8 |
| Name | Retapamulin |
| Molecular Formula | C30H47NO4S |
| Molecular Weight | 517.76 |
| Solubility | Soluble in DMSO ≥5mg/mL |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD11045316 |
| Target Point | Bacterial |
| Passage | Anti-infection |
| Background | Retapamulin is a topical antibiotic that binds Staphylococcus aureus and E. coli ribosomes. |
| Biological Activity | Retapamulin 是一种半合成的胸腺嘧啶衍生物，是一种局部抗生素用于治疗皮肤感染，可以结合大肠杆菌和金黄色葡萄球菌核糖体，Kd值为3 nM。[1-4] |
| In Vitro | 瑞他莫林能与细菌核糖体高亲和力结合，抑制核糖体肽基转移酶活性，并部分抑制启动子 tRNA 底物与核糖体 P 位点的结合。[1]雷他帕姆林对金黄色葡萄球菌和化脓性链球菌的 MIC(90)s 分别为 0.12 微克/毫升和 0.016 微克/毫升。[2]在 2 毫克/升或更低浓度下，瑞他莫林对 37/52 株(71%)脆弱拟杆菌属菌株和 85/87 株(98%)其他革兰氏阴性杆菌均有抑制作用。瑞他莫林对痤疮丙酸杆菌和厌氧革兰阳性球菌的活性高于克林霉素、甲硝唑和头孢曲松。[3]瑞他莫林可抑制对甲氧西林敏感的金黄色葡萄球菌和对甲氧西林耐药的金黄色葡萄球菌的蛋白质生物合成和细胞活力，抑制50S 核糖体亚基形成。[4] |
| Data Literature Source | [1]. Yan K，et al. Biochemical characterization of the interactions of the novel pleuromutilin derivative retapamulin with bacterial ribosomes. Antimicrob Agents Chemother. 2006 Nov;50(11):3875-81. [2]. Rittenhouse S，et al. Selection of retapamulin，a novel pleuromutilin for topical use. Antimicrob Agents Chemother. 2006 Nov;50(11):3882-5. [3]. Odou MF，et al. In vitro activity against anaerobes of retapamulin，a new topical antibiotic for treatment of skin infections. J Antimicrob Chemother. 2007 Apr;59(4):646-51. [4]. Champney WS，et al. Retapamulin inhibition of translation and 50S ribosomal subunit formation in Staphylococcus aureus cells. Antimicrob Agents Chemother. 2007 Sep;51(9):3385-7. |
| Unit | Bottle |
| Specification | 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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