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My CartCAS：22662-39-1
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 22662-39-1 |
| Name | Rafoxanide |
| Molecular Formula | C19H11Cl2I2NO3 |
| Molecular Weight | 626.01 |
| Solubility | Soluble in DMSO(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 245-148-9 |
| MDL | MFCD00682899 |
| SMILES | C1=CC(=CC=C1OC2=C(C=C(C=C2)NC(=O)C3=C(C(=CC(=C3)I)I)O)Cl)Cl |
| InChIKey | NEMNPWINWMHUMR-UHFFFAOYSA-N |
| InChI | InChI=1S/C19H11Cl2I2NO3/c20-10-1-4-13(5-2-10)27-17-6-3-12(9-15(17)21)24-19(26)14-7-11(22)8-16(23)18(14)25/h1-9，25H，(H，24，26) |
| PubChem CID | 31475 |
| Target Point | Parasite |
| Passage | Anti-infection |
| Background | Rafoxanide has antiparasitic activity and interferes with energy metabolism in fluke by uncoupling oxidative phosphorylation. |
| Biological Activity | Rafoxanide 是一种具有抗寄生虫活性的口服活性卤代水杨酰苯胺制剂，可用于控制绵羊和牛的血吸虫、法氏囊虫以及绵羊的卵黄囊虫，通过解除氧化磷酸化的耦合作用，干扰吸虫的能量代谢，能消灭反刍动物体内 91-99% 的成熟吸虫和 50-90% 的幼年吸虫。[1-3] |
| In Vitro | 野外寄生的Haemonchus contortus，对7.5 毫克/千克的碘醚柳胺具有明显的抗药性。[2] |
| In Vivo | 犊牛和绵羊皮下注射200微克/千克 的伊维菌素和2.5微克/千克碘醚柳胺组成的抗蠕虫药，以联合给药的形式诱导伊维菌素快速吸收，吸收半衰期缩短了 68.49%。[1] |
| Data Literature Source | [1]. El-Banna HA，et al. Comparative pharmacokinetics of ivermectin alone and a novel formulation of ivermectin and rafoxanide in calves and sheep. Parasitol Res. 2008 May;102(6):1337-42. [2]. van Wyk JA，et al. Two field strains of Haemonchus contortus resistant to rafoxanide. Onderstepoort J Vet Res. 1987 Jun;54(2):143-6. [3]. Sharma，S.et al. Salicylanilides. Approaches to Design and Synthesis of Antiparasitic Drugs，239–257. doi:10.1016/s0165-7208(97)80031-1. |
| Unit | Bottle |
| Specification | 500mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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