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My CartCAS：22204-24-6
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Light yellow to yellow Solid
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| CAS | 22204-24-6 |
| Name | Pyrantel Pamoate |
| Molecular Formula | C34H30N2O6S |
| Molecular Weight | 594.68 |
| Solubility | Soluble in DMSO(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 244-837-1 |
| MDL | MFCD00072037 |
| SMILES | CN1CCCN=C1C=CC2=CC=CS2.C1=CC=C2C(=C1)C=C(C(=C2CC3=C(C(=CC4=CC=CC=C43)C(=O)O)O)O)C(=O)O |
| InChIKey | AQXXZDYPVDOQEE-MXDQRGINSA-N |
| InChI | InChI=1S/C23H16O6.C11H14N2S/c24-20-16(14-7-3-1-5-12(14)9-18(20)22(26)27)11-17-15-8-4-2-6-13(15)10-19(21(17)25)23(28)29;1-13-8-3-7-12-11(13)6-5-10-4-2-9-14-10/h1-10，24-25H，11H2，(H，26，27)(H，28，29);2，4-6，9H，3，7-8H2，1H3/b;6-5+ |
| PubChem CID | 5281033 |
| Target Point | Parasite;nAChR |
| Passage | Anti-infection;Neuronal Signaling;Membrane Transporter&Ion Channel |
| Background | It is an effective repellent compound and a nicotinic acetylcholine receptor (nAChR) agonist. |
| Biological Activity | Pyrantel Pamoate 是一种口服活性抗蠕虫药，也是烟碱乙酰胆碱受体（nAChR）的激动剂，可导致寄生虫肌肉痉挛性麻痹。可用于研究蛔虫病、钩虫感染、肠道蠕虫（蛲虫感染）、旋毛虫病和毛滴虫病等寄生虫感染。[1-2] |
| In Vivo | 双羟萘酸噻嘧啶(10 nM-10 μM；72 小时)显示出良好的抗鼠蚁活性，(0-168.2 M；72 小时)显示出良好的抗美洲疟原虫活性。双羟萘酸噻嘧啶(10 mg/kg；p.o. ；单次)可减少感染 A. ceylanicum 的仓鼠体内的蠕虫，蠕虫负担减少率为 87.2%，驱虫率为 63.4%[2]。 |
| Data Literature Source | [1]. Martin RJ，et al. Oxantel is an N-type (methyridine and nicotine) agonist not an L-type (levamisole and pyrantel) agonist: classification of cholinergic anthelmintics in Ascaris. Int J Parasitol. 2004 Aug;34(9):1083-90. [2]. Tritten L，et al. In vitro and in vivo efficacy of Monepantel (AAD 1566) against laboratory models of human intestinal nematode infections. PLoS Negl Trop Dis. 2011 Dec;5(12):e1457. |
| Unit | Bottle |
| Specification | 50mg 100mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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