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My CartCAS：163680-77-1
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 163680-77-1 |
| Name | Pazufloxacin Mesylate |
| Molecular Formula | C17H19FN2O7S |
| Molecular Weight | 414.41 |
| Solubility | Soluble in Water/DMSO(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00913262 |
| SMILES | CC1COC2=C3N1C=C(C(=O)C3=CC(=C2C4(CC4)N)F)C(=O)O.CS(=O)(=O)O |
| InChIKey | UDHGFPATQWQARM-FJXQXJEOSA-N |
| InChI | InChI=1S/C16H15FN2O4.CH4O3S/c1-7-6-23-14-11(16(18)2-3-16)10(17)4-8-12(14)19(7)5-9(13(8)20)15(21)22;1-5(2，3)4/h4-5，7H，2-3，6，18H2，1H3，(H，21，22);1H3，(H，2，3，4)/t7-;/m0./s1 |
| PubChem CID | 6918232 |
| Target Point | Bacterial |
| Passage | Anti-infection |
| Background | It is a quinolone antibiotic. |
| Biological Activity | Pazufloxacin Mesylate 是一种新型喹诺酮衍生物，具有广谱的抗菌活性，对革兰氏阳性和阴性细菌都有很强的活性。[1-2] |
| In Vitro | 甲磺酸帕珠沙星(T-3761)在 90% 的受试菌株中，对革兰氏阳性菌(包括葡萄球菌属、链球菌属和肠球菌属)的 MIC 值为 0.20 至 100 微克/毫升；对革兰氏阴性菌(包括肠杆菌科和肠球菌属)的 MIC 值为 0.025 至 3. 13 微克/毫升，对革兰氏阴性菌，包括肠杆菌科和嗜血杆菌属的成员；0.05 至 50 微克/毫升，对葡萄糖不发酵菌，包括假单胞菌属、黄单胞菌属、醋氨单胞菌属、阿卡利根氏菌属和莫拉氏菌属的成员；0. 0.25 微克/毫升；对厌氧菌，包括脆弱拟杆菌属、艰难梭菌属和嗜酸链球菌属的活性为 6.25 至 25 微克/毫升。[1] T-3761 对 90% 的甲氧西林敏感金黄色葡萄球菌、甲氧西林敏感和耐药表皮葡萄球菌以及梭状芽孢杆菌的 MIC 为 0.39 至 6.25 微克/毫升。其活性与环丙沙星和氧氟沙星相当，比诺氟沙星和氟罗沙星高 4 至 8 倍，比托舒沙星低 2 至 8 倍。一些耐环丙沙星的金黄色葡萄球菌分离株对 T-3761 T-3761 的 MIC 值小于或等于 0.78 微克/毫升。T-3761 对 90% 的测试链球菌和肠球菌的 MIC 值为 3.13 至 100 微克/毫升。其活性相当于诺氟沙星和氟罗沙星的 2 倍或 4 倍，相当于氧氟沙星和环丙沙星的 2 倍或 4 倍，低于托舒沙星的 4 至 16 倍。T-3761 对革兰氏阴性菌的活性通常是诺氟沙星、氧氟沙星和氟罗沙星的四倍。[2] |
| In Vivo | 口服 T-3761 对小鼠全身、肺部和泌尿道感染的革兰氏阳性和革兰氏阴性细菌(包括耐喹诺酮的大肠沙雷氏菌和铜绿假单胞菌)具有良好的疗效。在大多数小鼠感染模型中，T-3761 的体内活性与氧氟沙星、环丙沙星、诺氟沙星和替舒沙星相当或高于它们。T-3761 对小鼠全身和肺部革兰氏阳性细菌感染的活性低于托舒沙星，但对耐甲氧西林金黄色葡萄球菌感染的活性则低于托舒沙星。T-3761 对小鼠全身耐喹诺酮类药物的大肠沙雷氏菌和铜绿假单胞菌感染的活性是参考药物的 2 到 14 倍。[1] |
| Data Literature Source | [1]. Fukuoka Y，et al. In vitro and in vivo antibacterial activities of T-3761，a new quinolone derivative. Antimicrob Agents Chemother. 1993 Mar;37(3):384-92. [2]. Muratani T，et al. In vitro activity of T-3761，a new fluoroquinolone. Antimicrob Agents Chemother. 1992 Oct;36(10):2293-303. |
| Unit | Bottle |
| Specification | 100mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
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