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My CartCAS：6054-98-4
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥97%
Appearance：Light yellow to yellow Solid
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| CAS | 6054-98-4 |
| Name | Olsalazine Sodium |
| Molecular Formula | C14H8N2Na2O6 |
| Molecular Weight | 346.2 |
| Solubility | Soluble in Water/DMSO(Need ultrasonic) |
| Purity | ≥97% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 227-975-7 |
| MDL | MFCD00013300 |
| Target Point | Bacterial |
| Passage | Anti-infection |
| Background | Sodium Olsalazine is an anti-inflammatory compound which can be used in the study of inflammatory bowel disease and ulcerative colitis. |
| Biological Activity | Olsalazine Sodium 是一种抗炎药物，包含2个5-ASA部分，用于治疗炎症性肠病和溃疡性结肠炎。[1] |
| In Vitro | 柳氮磺胺吡啶、奥沙拉秦钠和 5-ASA 是巨噬细胞对 LTB4 趋化的强效抑制剂，其 IC50 值分别为 0.43、0.39 和 0.24 毫摩尔。这些浓度低于慢性炎症性肠病患者接受常规柳氮磺胺吡啶治疗时结肠腔内 5-ASA 的最低浓度(2 mM)。[2]奥沙拉秦钠(0.4 mM)抑制佛波酯(PMA)-活化的中性粒细胞，或通过黄嘌呤-黄嘌呤氧化酶反应产生的超氧游离基产物，使其分别减少31%和73%。[3] |
| In Vivo | 奥沙拉秦钠是一种抗炎药物，旨在将其活性分子美沙拉秦(5-氨基水杨酸；mesalamine)输送到结肠，同时避免使用磺胺吡啶载体带来的不良反应。每日分次服用 1 至 3 克奥沙拉秦可改善约 60% 至 80% 轻度至中度急性溃疡性结肠炎患者的结肠炎临床症状和体征。较小剂量的奥沙拉秦(通常每天 1 克，分次服用)也能维持慢性溃疡性结肠炎患者病情的缓解。[1]奥沙拉秦钠能够改善DSS诱发的肠道炎症，其活性治疗分子主要是释放出的 5-ASA 分子。对患有葡聚糖硫酸钠诱发的实验性结肠炎的nu/nu CD-1小鼠，奥沙拉秦钠(50 毫克/千克/天)将存活期显著延长至 38 天，在 10 至 100 毫克/千克/天的范围内表现出剂量依赖性效应，与人类使用的剂量接近。[4]奥沙拉秦钠对 1，2 二甲基肼处理过的大鼠结肠异常隐窝和肿瘤的抑制能力，能有效减少肿瘤数量和负荷，提高肿瘤凋亡率，降低肿瘤细胞增殖率。[5] |
| Data Literature Source | [1]. Wadworth AN，et al. Olsalazine. A review of its pharmacodynamic and pharmacokinetic properties，and therapeutic potential in inflammatory bowel disease. Drugs. 1991 Apr;41(4):647-64. [2]. Nielsen OH，et al. Inhibition of intestinal macrophage chemotaxis to leukotriene B4 by sulphasalazine，olsalazine，and 5-aminosalicylic acid. Aliment Pharmacol Ther. 1988 Jun;2(3):203-11. [3]. Gionchetti P，et al. Scavenger effect of sulfasalazine，5-aminosalicylic acid，and olsalazine on superoxide radical generation. Dig Dis Sci. 1991 Feb;36(2):174-8. [4]. Axelsson LG，et al. Experimental colitis induced by dextran sulphate sodium in mice: beneficial effects of sulphasalazine and olsalazine. Aliment Pharmacol Ther. 1998 Sep;12(9):925-34. [5]. Brown WA，et al. 5-aminosalicyclic acid and olsalazine inhibit tumor growth in a rodent model of colorectal cancer. Dig Dis Sci. 2000 Aug;45(8):1578-84. |
| Unit | Bottle |
| Specification | 500mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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