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My CartCAS：1256388-51-8
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Light yellow to yellow Solid
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| CAS | 1256388-51-8 |
| Name | Ledipasvir |
| Molecular Formula | C49H54F2N8O6 |
| Molecular Weight | 889 |
| Solubility | Soluble in DMSO ≥5mg/mL |
| Purity | ≥98% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD25976756 |
| SMILES | CC(C)[C@@H](C(=O)N1CC2(CC2)C[C@H]1C3=NC=C(N3)C4=CC5=C(C=C4)C6=C(C5(F)F)C=C(C=C6)C7=CC8=C(C=C7)N=C(N8)[C@@H]9[C@H]1CC[C@H](C1)N9C(=O)[C@H](C(C)C)NC(=O)OC)NC(=O)OC |
| InChIKey | VRTWBAAJJOHBQU-KMWAZVGDSA-N |
| InChI | InChI=1S/C49H54F2N8O6/c1-24(2)39(56-46(62)64-5)44(60)58-23-48(15-16-48)21-38(58)42-52-22-37(55-42)28-9-13-32-31-12-8-26(18-33(31)49(50，51)34(32)19-28)27-10-14-35-36(20-27)54-43(53-35)41-29-7-11-30(17-29)59(41)45(61)40(25(3)4)57-47(63)65-6/h8-10，12-14，18-20，22，24-25，29-30，38-41H，7，11，15-17，21，23H2，1-6H3，(H，52，55)(H，53，54)(H，56，62)(H，57，63)/t29-，30+，38-，39-，40-，41-/m0/s1 |
| PubChem CID | 67505836 |
| Target Point | HCV |
| Passage | Anti-infection |
| Background | Ledipasvir is a potent HCV NS5A inhibitor that inhibits GT1a and GT1b replicator M. |
| Biological Activity | Ledipasvir 是丙型肝炎病毒 NS5A 的抑制剂，对基因型 1a 和 1b 复制子的 EC50 分别为 34 pM 和 4 pM。也是一种 SARS-CoV 3CLpro 抑制剂，IC50 为 1.62 μM。[31-] |
| In Vitro | 雷迪帕韦的GT1a和1b EC50值分别为31和4 pM，蛋白调整EC50值分别为210 pM(GT1a)和27 pM(GT1b)，GT1a和GT1b的固有EC50值分别为310 fM和40 fM。在人血清和复制子试验的细胞培养基(含 10% BSA)中，Ledipasvir 与蛋白质高度结合。[1]雷迪帕韦对 JFH/3a-NS5A 复制子的 EC50 值为 141 nM。[2] |
| In Vivo | 雷迪帕韦不仅复制效力高，而且清除率低，生物利用度高，在大鼠、狗和猴子体内的半衰期长，在人体内的预测清除率低。在大鼠和狗体内测定了雷迪帕韦的药代动力学。雷迪帕韦在血浆中的半衰期较长(大鼠为 1.83 ± 0.22 小时，狗为 2.63 ± 0.18 小时)，全身清除率(CL)较低，分布容积(Vss)适中，大于体内总水量。[1] |
| Data Literature Source | [1]. Link JO，et al. Discovery of ledipasvir (GS-5885): a potent，once-daily oral NS5A inhibitor for the treatment of hepatitis C virus infection. J Med Chem. 2014 Mar 13;57(5):2033-46. doi: 10.1021/jm401499g. Epub 2014 Jan 10. Erratum in: J Med Chem. 2016 Aug 25;59(16):7696. [2]. Hernandez D，et al. Natural prevalence of NS5A polymorphisms in subjects infected with hepatitis C virus genotype 3 and their effects on the antiviral activity of NS5A inhibitors. J Clin Virol. 2013 May;57(1):13-8. [3]. Sun Q，et al. Bardoxolone and bardoxolone methyl，two Nrf2 activators in clinical trials，inhibit SARS-CoV-2 replication and its 3C-like protease. Signal Transduct Target Ther. 2021 May 29;6(1):212. |
| Unit | Bottle |
| Specification | 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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